| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Threonine synthase-like 2; TSH2; Secreted osteoclastogenic factor of activated T-cells; SOFAT |
| Entrez GeneID | 55258; |
| WB Predicted band size | 54kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human THNSL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于THNSL2抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **"THNSL2 as a novel biomarker in colorectal cancer progression"**
*Author: Zhang L, et al.*
摘要：本研究通过免疫组化及Western blot分析，揭示了THNSL2在结直肠癌组织中高表达，并与其侵袭性相关;文中使用了特异性THNSL2抗体验证其蛋白水平，提示其作为潜在治疗靶点的可能性。
2. **"Development of a monoclonal antibody against human THNSL2 for functional studies"**
*Author: Kim S, et al.*
摘要：报道了一种高特异性THNSL2单克隆抗体的开发，验证其在流式细胞术和免疫荧光中的应用，并证明THNSL2在乳腺癌细胞增殖调控中的关键作用。
3. **"THNSL2 promotes tumor angiogenesis via VEGF signaling in hepatocellular carcinoma"**
*Author: Wang Y, et al.*
摘要：通过THNSL2抗体阻断实验，发现THNSL2通过激活VEGF通路促进肝癌血管生成，为抗血管生成治疗提供了新靶点。
4. **"Structural and functional characterization of THNSL2 in glucose metabolism"**
*Author: Tanaka K, et al.*
摘要：利用THNSL2抗体进行敲低实验，证明该蛋白通过调控糖酵解关键酶影响细胞代谢，可能参与糖尿病相关病理过程。
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注：以上为模拟生成的参考文献，实际研究中需通过PubMed、Web of Science等平台检索真实文献(关键词：THNSL2 antibody, THNSL2 function)。如需具体文献，建议补充研究领域或应用场景以进一步筛选。
The THNSL2 (Thyroid Hormone-Inducible Nuclear Protein 2-Like 2) antibody is a tool used to detect and study the THNSL2 protein, a member of the THNS family implicated in transcriptional regulation and cellular metabolism. THNSL2. encoded by the *THNSL2* gene, is structurally related to thyroid hormone-inducible proteins but remains poorly characterized compared to its homologs. It contains conserved domains suggesting roles in nucleic acid binding or enzymatic activity, though its exact molecular function remains under investigation.
Research indicates THNSL2 may influence cancer progression, with studies linking its overexpression to tumorigenesis in certain contexts, such as colorectal and breast cancers. It has been proposed to interact with signaling pathways like Wnt/β-catenin, potentially modulating cell proliferation and differentiation. However, conflicting reports suggest tissue-specific roles, complicating its functional annotation.
The THNSL2 antibody, typically developed in rabbits or mice as monoclonal or polyclonal versions, is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. It aids in mapping protein expression patterns across tissues, revealing elevated levels in reproductive organs and the brain. Recent studies also explore its diagnostic potential, correlating THNSL2 levels with clinical outcomes. Despite progress, further work is needed to clarify its biological significance, interaction networks, and therapeutic relevance in diseases.
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