Rabbit Polyclonal FUK Antibody

The FUK antibody is designed to target fucokinase (FUK), an enzyme critical in the fucose metabolism pathway. Fucokinase catalyzes the ATP-dependent phosphorylation of L-fucose to form fucose-1-phosphate, a key step in the salvage pathway that enables the incorporation of free fucose into glycoconjugates like glycoproteins and glycolipids. These fucose-containing molecules play essential roles in cellular processes such as cell-cell adhesion, immune response modulation, and pathogen recognition. Dysregulation of fucose metabolism has been implicated in several diseases, including cancer, congenital disorders of glycosylation, and inflammatory conditions. The FUK antibody is widely used in research to investigate FUK expression levels, localization, and function in both normal and pathological states. It serves as a tool for techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of how fucose metabolism impacts cellular behavior or disease progression. Recent studies have highlighted FUK's potential role in cancer metastasis, where altered fucosylation patterns on cell surfaces may promote tumor invasiveness. By enabling precise detection of FUK protein, this antibody contributes to advancing our understanding of glycosylation-related mechanisms and their therapeutic targeting.