| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KIAA0799; Unconventional myosin-X; Unconventional myosin-10 |
| Entrez GeneID | 4651; |
| WB Predicted band size | 250190kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MYO10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MYO1抗体的3篇参考文献及其简要摘要：
1. **文献名称**: "Myosin 1b regulates the actin cytoskeleton and cell migration in response to growth factor signaling"
**作者**: Tang, H., et al.
**摘要**: 该研究利用特异性MYO1B抗体探究了其在生长因子诱导的细胞迁移中的作用，发现MYO1B通过调控肌动蛋白网络重组影响细胞运动能力。
2. **文献名称**: "Localization of myosin 1a in intestinal epithelial cells using a novel monoclonal antibody"
**作者**: Tyska, M.J., et al.
**摘要**: 研究团队开发了一种新型MYO1A单克隆抗体，通过免疫荧光证实MYO1A在小肠上皮细胞微绒毛中的定位，支持其在膜-细胞骨架连接中的功能假说。
3. **文献名称**: "Dysregulated myosin 1e expression in lupus nephritis revealed by proteomic analysis"
**作者**: Zhang, L., et al.
**摘要**: 采用MYO1E特异性抗体进行蛋白质组学分析，发现狼疮性肾炎患者肾组织中MYO1E异常高表达，提示其可能参与足细胞损伤的病理过程。
注：以上文献为示例性质，实际引用时建议通过PubMed等数据库核对最新研究。MYO1家族包含多个亚型(如MYO1A/B/C等)，研究时需注意抗体特异性及靶标亚型匹配。
MYO1 antibodies target members of the myosin 1 (MYO1) family, a group of actin-dependent motor proteins involved in diverse cellular processes. MYO1 proteins belong to the myosin superfamily, characterized by an N-terminal motor domain that binds actin and hydrolyzes ATP, enabling mechanical force generation, and a C-terminal tail domain that mediates interactions with cellular membranes or other cargoes. Unlike conventional myosins, MYO1 isoforms (e.g., MYO1A to MYO1H in humans) are single-headed and function as molecular linkers between the actin cytoskeleton and lipid bilayers. They play roles in membrane remodeling, vesicle trafficking, mechanotransduction, and maintaining cell polarity.
MYO1 antibodies are essential tools for studying the localization, expression, and functional roles of these proteins. For example, MYO1A is linked to auditory hair cell function, while MYO1C regulates nuclear transcription and glucose transport. Dysregulation of MYO1 proteins has been implicated in cancers, neurological disorders, and hearing loss. Researchers use MYO1-specific antibodies (polyclonal or monoclonal) in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore their contributions to cellular dynamics and disease mechanisms. These antibodies help clarify MYO1 isoform-specific interactions with signaling pathways or cytoskeletal networks, advancing insights into their therapeutic potential.
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