| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UEV3; Ubiquitin-conjugating enzyme E2 variant 3; UEV-3; EV and lactate/malate dehydrogenase domain-containing protein |
| Entrez GeneID | 55293; |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human UEVLD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **UEVLD抗体** 的3篇参考文献示例(内容为虚构，仅供示例参考)：
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1. **文献名称**: *"UEVLD Antibody Characterization in Viral Immune Evasion"*
**作者**: Zhang et al.
**摘要**: 研究通过生成特异性UEVLD抗体，揭示其在病毒(如HIV)出芽过程中与宿主蛋白TSG101的相互作用，证明UEVLD通过泛素化途径调控病毒释放，为抗病毒治疗提供新靶点。
2. **文献名称**: *"Diagnostic Potential of Anti-UEVLD Antibodies in Colorectal Cancer"*
**作者**: Li et al.
**摘要**: 分析UEVLD蛋白在结直肠癌组织中的异常表达，开发高灵敏度UEVLD抗体用于免疫组化检测，发现其表达水平与肿瘤转移和患者预后显著相关。
3. **文献名称**: *"UEVLD Antibody Reveals a Role in DNA Damage Repair"*
**作者**: Wang et al.
**摘要**: 利用UEVLD抗体阻断细胞核内泛素化信号，证实UEVLD与RNF8/RNF168协同参与DNA双链断裂修复，影响基因组稳定性及癌症发生机制。
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*注：以上文献为模拟内容，实际研究中请查阅PubMed、Google Scholar等平台获取真实数据。*
**Background of UEVLD Antibodies**
UEVLD (Ubiquitin-conjugating Enzyme Variant Ligase-Damaged) antibodies are tools used to study proteins involved in ubiquitination, a critical post-translational modification regulating processes like protein degradation, DNA repair, and signal transduction. UEVLD proteins, part of the ubiquitin-conjugating enzyme (E2) family, interact with E3 ligases to facilitate substrate-specific ubiquitination. Unlike canonical E2 enzymes, UEVLD lacks catalytic cysteine residues, suggesting regulatory or adaptor roles in ubiquitin signaling.
UEVLD is implicated in maintaining genomic stability and stress responses. Studies link it to the Fanconi anemia (FA) pathway, which repairs DNA interstrand crosslinks, and to interactions with key proteins like BRCA1. Dysregulation of UEVLD-associated pathways is observed in cancers and neurodegenerative diseases, highlighting its therapeutic relevance.
Antibodies targeting UEVLD enable detection, localization, and functional analysis in cells and tissues. They are crucial for Western blotting, immunofluorescence, and co-immunoprecipitation experiments to explore UEVLD’s interaction networks and mechanistic roles. Recent research focuses on UEVLD’s involvement in tumor suppression, chemoresistance, and cellular stress adaptation, driving demand for specific, high-affinity antibodies. Commercial UEVLD antibodies are typically validated in knockout models to ensure specificity, supporting both basic research and drug discovery efforts targeting ubiquitination-related pathologies.
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