Rabbit Polyclonal TMEM145 Antibody

The TMEM145 antibody is a research tool designed to target the transmembrane protein 145 (TMEM145), a poorly characterized protein encoded by the human *TMEM145* gene. TMEM145 is predicted to be a multi-pass membrane protein, though its exact physiological role remains unclear. Preliminary studies suggest potential involvement in intracellular membrane trafficking, organelle dynamics, or ion transport, given its structural similarity to other transmembrane transporters. The antibody is typically developed in host species like rabbits or mice using immunogenic peptides corresponding to specific epitopes of TMEM145. often validated through techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Researchers utilize this reagent to investigate TMEM145's expression patterns, subcellular localization (e.g., endoplasmic reticulum, Golgi apparatus), and potential associations with diseases such as cancer or neurodegenerative disorders. Challenges include limited commercial availability and the need for rigorous validation due to TMEM145's low expression levels and possible cross-reactivity with unrelated proteins. Recent studies (as of 2023) have begun exploring its interaction networks using TMEM145 antibodies in proteomic analyses, aiming to clarify its biological significance. This antibody remains critical for advancing the functional characterization of this enigmatic protein.