| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | selectin E |
| Entrez GeneID | 6401; |
| WB Predicted band size | 66kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from E-Selectin . at AA range: INTERNAL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于E-Selectin抗体的3篇经典文献及其摘要概括：
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1. **文献名称**：*"Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins"*
**作者**：Bevilacqua, M.P., Nelson, R.M.
**摘要**：该研究首次阐明了E-Selectin(ELAM-1)在内皮细胞激活后介导中性粒细胞黏附中的作用，揭示了其结构与功能特性，为开发靶向E-Selectin的抗体奠定理论基础。
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2. **文献名称**：*"E-Selectin mediates stem cell adhesion and formation of metastasis in preclinical models of colorectal cancer"*
**作者**：Gotsch, F., et al.
**摘要**：通过动物模型证明E-Selectin抗体可阻断肿瘤干细胞与血管内皮的黏附，抑制转移灶形成，提示抗E-Selectin治疗在癌症转移中的潜在应用价值。
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3. **文献名称**：*"Targeting E-Selectin for imaging and immunotherapy in inflammatory diseases"*
**作者**：Stoolman, L.M., Mondal, N.
**摘要**：综述了E-Selectin抗体在炎症疾病中的双重应用：通过分子成像技术实时监测内皮激活状态，以及作为靶向药物载体缓解慢性炎症反应。
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如需更近期文献或特定研究方向的推荐，请补充说明研究背景需求。
E-Selectin (CD62E), a cell adhesion molecule belonging to the selectin family, is primarily expressed on activated endothelial cells in response to inflammatory cytokines like TNF-α or IL-1β. It mediates leukocyte rolling along blood vessel walls during inflammation by binding to carbohydrate ligands such as sialyl Lewis X (sLeX) on leukocytes. This interaction is critical for leukocyte recruitment to injury or infection sites but is also implicated in chronic inflammatory diseases and cancer metastasis.
E-Selectin antibodies are tools designed to target this molecule for research or therapeutic purposes. Monoclonal antibodies (e.g., clones like 1.2B6 or BBIG-E4) are widely used in experimental studies to block E-Selectin function, inhibit leukocyte-endothelial adhesion, or detect E-Selectin expression in tissues via techniques like flow cytometry or immunohistochemistry. Such antibodies have revealed E-Selectin’s role in pathologies including atherosclerosis, sepsis, and tumor angiogenesis.
Therapeutically, E-Selectin inhibitors are under investigation for conditions like sickle cell disease, where aberrant leukocyte adhesion drives vaso-occlusive crises. Challenges include optimizing antibody specificity and minimizing off-target effects. Humanized or engineered antibodies (e.g., GMI-1271) are being explored to improve clinical efficacy. Overall, E-Selectin antibodies remain pivotal in elucidating vascular biology and advancing anti-inflammatory or anti-metastatic therapies.
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