Rabbit Polyclonal NTNG2 Antibody

The NTNG2 antibody is designed to detect Netrin-G2 (NTNG2), a member of the netrin family of secreted and membrane-associated proteins involved in axon guidance and synaptic connectivity. NTNG2. encoded by the *NTNG2* gene, is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in the central nervous system (CNS). It plays a critical role in neural development by mediating cell-cell interactions and regulating synapse formation through its interaction with leucine-rich repeat (LRR)-containing receptors, such as Laminet family members and LRRC4C. NTNG2 is implicated in establishing precise neural circuits, particularly in the thalamocortical and limbic systems. Dysregulation of NTNG2 has been linked to neurodevelopmental and psychiatric disorders, including schizophrenia, autism spectrum disorders, and bipolar disorder. Antibodies targeting NTNG2 are essential tools in neuroscience research, enabling the visualization and quantification of NTNG2 expression in tissues or cultured cells via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF). These antibodies aid in studying NTNG2's functional roles, its interaction networks, and its potential as a biomarker or therapeutic target in neurological diseases. Validation of NTNG2 antibodies typically includes specificity tests using knockout controls or recombinant proteins to ensure accurate detection.