| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SGY; CT34; SGY1; SGY-1 |
| Entrez GeneID | 50722; |
| WB Predicted band size | 27kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic protein corresponding to residues near the C terminal of human DKKL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DKKL1抗体的参考文献示例(注：以下内容为假设性示例，仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of DKKL1 Antibody and Its Role in Testicular Development"*
**作者**: Smith J. et al. (2018)
**摘要**: 该研究开发了一种特异性DKKL1抗体，用于检测小鼠睾丸组织中的DKKL1蛋白表达，发现其在精子发生的减数分裂阶段显著上调，提示DKKL1可能参与生殖细胞分化调控。
2. **文献名称**: *"DKKL1/Soggy Protein Localization in Human Germ Cells Using Monoclonal Antibodies"*
**作者**: Zhang L. et al. (2020)
**摘要**: 通过制备单克隆抗体，研究者利用免疫组化和Western blot技术揭示了DKKL1在人类精原细胞中的特异性定位，表明其在维持生殖细胞稳态中的潜在作用。
3. **文献名称**: *"Functional Analysis of DKKL1 Knockout Mice via Antibody-Based Phenotyping"*
**作者**: Tanaka K. et al. (2019)
**摘要**: 研究利用抗体验证DKKL1基因敲除小鼠模型中蛋白表达的缺失，发现其与精子形态异常及雄性不育表型相关，提示DKKL1为精子形成的关键因子。
4. **文献名称**: *"DKKL1 Interaction with Wnt Signaling Components: Insights from Co-Immunoprecipitation Studies"*
**作者**: Lee S. et al. (2021)
**摘要**: 通过DKKL1抗体进行免疫共沉淀实验，发现其与Wnt通路蛋白存在物理相互作用，为DKKL1在睾丸发育中调控信号通路的机制提供了证据。
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**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文，并核对作者、年份及摘要准确性。
The DKKL1 (Dickkopf-like protein 1) antibody is a tool used to study the DKKL1 protein, a member of the Dickkopf (DKK) family. Unlike canonical DKK proteins (e.g., DKK1-4), which are known Wnt signaling antagonists, DKKL1 shares structural homology but exhibits distinct functional roles. Primarily expressed in the testis and brain, DKKL1 is implicated in spermatogenesis, neurodevelopment, and immune regulation. Its precise mechanisms remain under investigation, though studies suggest involvement in cell differentiation, apoptosis, and tissue homeostasis.
DKKL1 antibodies are essential for detecting protein expression, localization, and interactions in experimental models. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into DKKL1's biological significance. Abnormal DKKL1 expression has been linked to conditions such as male infertility, neurodegenerative disorders, and cancers, highlighting its potential as a diagnostic or therapeutic target. Commercial DKKL1 antibodies are typically developed using immunogenic peptides or recombinant proteins, with validation across species and applications. Ongoing studies aim to clarify DKKL1's dual roles in development and disease, emphasizing the antibody's utility in bridging molecular insights with clinical relevance.
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