| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RCN3; MCIP3; hRCN3; DSCR1L2 |
| Entrez GeneID | 53902; |
| WB Predicted band size | 27kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the N terminal of human RCAN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RCAN3抗体的3篇参考文献示例(注：以下内容为虚构，仅用于演示格式)：
1. **文献名称**：*RCAN3 Antibody Characterization in Down Syndrome Models*
**作者**：Smith J, et al.
**摘要**：研究验证了RCAN3抗体在唐氏综合征小鼠脑组织中的特异性，发现RCAN3表达水平与钙调神经磷酸酶活性呈负相关。
2. **文献名称**：*Role of RCAN3 in Cardiac Hypertrophy: Antibody-Based Detection*
**作者**：Lee H, et al.
**摘要**：通过RCAN3抗体分析发现，其在压力超负荷诱导的小鼠心肌肥厚模型中表达显著上调，提示其可能通过调控钙信号通路参与病理过程。
3. **文献名称**：*RCAN3 Antibody Application in Neurodegenerative Disease Studies*
**作者**：Garcia R, et al.
**摘要**：研究利用RCAN3抗体检测阿尔茨海默病模型中的蛋白分布，发现其与tau蛋白异常磷酸化存在空间共定位，提示潜在病理关联。
4. **文献名称**：*Development of a High-Specificity RCAN3 Monoclonal Antibody*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型RCAN3单克隆抗体的制备与验证，通过免疫印迹和免疫组化证实其在多种组织中的高灵敏度和低交叉反应性。
(注：以上文献及作者为虚构，实际研究中建议通过PubMed或Web of Science等平台检索真实文献。)
The RCAN3 (Regulator of Calcineurin 3) antibody is a tool used to detect and study the RCAN3 protein, a member of the RCAN family that modulates calcineurin, a calcium-dependent phosphatase involved in critical cellular processes like immune response, muscle development, and neuronal signaling. RCAN3. encoded by the RCAN3 gene, is less characterized compared to other family members (RCAN1/2) but is implicated in regulating calcineurin-NFAT (nuclear factor of activated T-cells) signaling pathways. Dysregulation of this pathway is linked to pathologies including Down syndrome, cardiovascular diseases, and neurodegeneration.
RCAN3 antibodies are commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore RCAN3's expression, localization, and interaction networks. Studies suggest RCAN3 may play roles in stress adaptation, cell cycle control, and apoptosis, though its exact biological functions remain unclear. Research using RCAN3 antibodies has revealed its widespread tissue distribution, with notable expression in the brain, heart, and skeletal muscles, hinting at tissue-specific regulatory mechanisms.
Despite its potential significance, RCAN3 research is limited by antibody specificity challenges and a lack of comprehensive functional studies. Validated RCAN3 antibodies are essential for clarifying its role in calcineurin signaling crosstalk and disease contexts. Commercial antibodies are available, but rigorous validation using knockout controls is recommended to ensure reliability. Ongoing work aims to uncover RCAN3's contributions to cellular homeostasis and its therapeutic relevance in calcineurin-associated disorders.
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