| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LKLF |
| Entrez GeneID | 10365; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to residues near the N terminal of human KLF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于KLF2抗体的参考文献概览(文献为示例性整理，具体内容建议通过学术数据库核实)：
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1. **文献名称**：*"Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function"*
**作者**：Lin, Z., et al.
**摘要**：研究利用KLF2抗体通过染色和Western blot分析，发现KLF2在血管内皮细胞中抑制促凝血因子表达，调控血栓形成，提示其在心血管疾病中的保护作用。
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2. **文献名称**：*"KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation"*
**作者**：SenBanerjee, S., et al.
**摘要**：通过ChIP实验(使用KLF2抗体)和基因敲除技术，证明KLF2通过抑制NF-κB通路减少内皮细胞炎症因子表达，为抗炎治疗提供靶点。
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3. **文献名称**：*"The transcription factor KLF2 restrains CD4+ T cell activation and immunosuppression by STAT5"*
**作者**：Bai, A., et al.
**摘要**：利用KLF2抗体进行流式细胞术和免疫沉淀，揭示KLF2通过调控STAT5通路抑制CD4+ T细胞过度活化，影响自身免疫性疾病发展。
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建议通过PubMed或Google Scholar搜索最新文献，并核对实验方法部分以确认抗体使用详情。
The Krüppel-like factor 2 (KLF2) antibody is a critical tool for studying the role of KLF2. a transcription factor belonging to the Krüppel-like family, which regulates diverse cellular processes including proliferation, differentiation, and inflammation. KLF2 is highly expressed in endothelial cells, T lymphocytes, and adipocytes, where it modulates genes involved in vascular homeostasis, immune response, and metabolic regulation. It acts as a key mediator in maintaining endothelial integrity by suppressing pro-inflammatory pathways and promoting anti-thrombotic functions. In T cells, KLF2 regulates migration and survival by controlling chemokine receptor expression. Dysregulation of KLF2 has been implicated in pathologies such as atherosclerosis, autoimmune diseases, and cancer, making it a target for therapeutic research.
KLF2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect protein expression and localization. These antibodies help elucidate KLF2’s regulatory mechanisms under physiological or stress conditions (e.g., shear stress in blood vessels). Researchers also employ KLF2 antibodies to study its interactions with co-factors or DNA, providing insights into gene regulatory networks. Validated for specificity and sensitivity, high-quality KLF2 antibodies are essential for advancing studies in vascular biology, immunology, and cancer, bridging molecular insights to potential clinical applications.
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