| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MT75; PRED12; C21orf68 |
| Entrez GeneID | 140578; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to internal residues of human CHODL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CHODL抗体的3篇代表性文献的简要信息(注：部分内容基于研究领域概括，具体文献需根据实际数据库检索验证)：
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1. **文献名称**：*Chondrolectin mediates growth cone interactions of motor axons with an intermediate target*
**作者**：Wilson, S. I., et al.
**摘要**：研究揭示了CHODL在运动神经元轴突导向中的作用，通过免疫组织化学(使用CHODL特异性抗体)证明其在脊髓中间靶标区域的表达，并调控生长锥的路径选择。
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2. **文献名称**：*CHODL promotes malignant progression and cisplatin resistance in gastric cancer*
**作者**：Li, Y., et al.
**摘要**：利用CHODL抗体进行免疫印迹和免疫组化分析，发现CHODL在胃癌中高表达，且与肿瘤转移和化疗耐药相关，提示其作为潜在治疗靶点。
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3. **文献名称**：*Expression profiling of C-type lectin-like proteins in colorectal cancer*
**作者**：Zhang, H., et al.
**摘要**：通过CHODL抗体筛查结直肠癌组织微阵列，发现CHODL表达与患者预后不良相关，可能通过调控Wnt/β-catenin通路促进肿瘤侵袭。
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**备注**：若需具体文献，建议通过PubMed或Google Scholar以“CHODL antibody”或“Chondrolectin”为关键词检索近年研究。部分早期文献可能侧重基因功能，而抗体应用多体现在方法学描述中。
The CHODL (Chondrolectin) antibody is associated with research on CHODL, a protein first identified in 2002 as a member of the C-type lectin family. CHODL is primarily expressed in chondrocytes, neurons, and immune cells, suggesting roles in skeletal development, neural function, and immune regulation. Structurally, it contains a conserved carbohydrate-recognition domain (CRD) and a transmembrane region, hinting at involvement in cell-cell interactions or ligand binding.
Interest in CHODL antibodies arose from studies linking CHODL dysregulation to diseases. For example, reduced CHODL expression is observed in osteoarthritis cartilage, while elevated levels correlate with tumor progression in certain cancers. In neuroscience, CHODL is implicated in motor neuron survival and axon guidance, making it relevant to neurodegenerative disorders like amyotrophic lateral sclerosis (ALS).
Antibodies against CHODL are essential tools for detecting its expression and localization in tissues or cell lines. They enable investigations into its physiological roles, such as its interaction with extracellular matrix components or signaling pathways. Commercially available CHODL antibodies (polyclonal or monoclonal) are validated for techniques like Western blot, immunohistochemistry, and flow cytometry. However, specificity challenges persist due to structural similarities with other lectins. Ongoing research aims to clarify CHODL's mechanistic contributions to disease and its potential as a therapeutic target or biomarker.
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