| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IRP; INT1L1 |
| Entrez GeneID | 7472; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human WNT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于WNT2抗体的3篇代表性文献摘要(基于公开研究整理，非实时数据)：
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1. **文献名称**: *WNT2 overexpression promotes tumor progression and immune evasion in non-small cell lung cancer*
**作者**: Yokoyama N, et al.
**摘要**: 研究通过免疫组化(使用抗WNT2抗体)发现WNT2在非小细胞肺癌(NSCLC)中高表达，且与患者预后不良相关。机制上，WNT2通过激活β-catenin信号通路促进肿瘤增殖，并抑制CD8+ T细胞浸润，导致免疫逃逸。
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2. **文献名称**: *WNT2B regulates proliferation and survival of colorectal cancer cells via activation of the Wnt/β-catenin pathway*
**作者**: Saitoh T, et al.
**摘要**: 该研究利用WNT2特异性抗体进行Western blot和免疫荧光实验，证实结直肠癌细胞中WNT2B通过结合Frizzled受体激活经典Wnt通路，促进细胞增殖并抑制凋亡，提示其作为潜在治疗靶点。
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3. **文献名称**: *WNT2 as a biomarker for gastric cancer-associated fibroblasts*
**作者**: Katoh M, et al.
**摘要**: 研究使用WNT2抗体检测胃癌微环境中癌症相关成纤维细胞(CAFs)的WNT2分泌水平，发现WNT2高表达与肿瘤侵袭性增强和化疗耐药相关，提示其可作为胃癌预后标志物。
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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或Google Scholar以“WNT2 antibody”为关键词检索最新研究，并核对作者及期刊信息。
The Wnt family member 2 (WNT2) antibody is a crucial tool for studying the WNT2 protein, a secreted glycoprotein involved in the evolutionarily conserved Wnt signaling pathway. WNT2 plays a pivotal role in regulating cell proliferation, differentiation, and tissue development by activating both canonical (β-catenin-dependent) and non-canonical signaling pathways. It is implicated in embryogenesis, organogenesis, and tissue homeostasis, particularly in lung, gut, and placental development. Dysregulation of WNT2 has been linked to cancers (e.g., colorectal, gastric), fibrosis, and metabolic disorders, making it a target for therapeutic research.
WNT2 antibodies are designed to detect and quantify endogenous WNT2 protein in various experimental applications, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies are typically raised in hosts like rabbits or mice using immunogenic peptides or recombinant WNT2 protein fragments. Validation parameters include specificity (confirmed by knockout controls or siRNA knockdown), cross-reactivity assessment across species, and performance in target applications. High-quality WNT2 antibodies enable researchers to map protein localization, study signaling dynamics, and explore disease mechanisms. Recent studies also highlight their potential in characterizing WNT2's dual role as both an oncogene and tumor suppressor, depending on cellular context. Proper antibody selection requires attention to epitope regions, post-translational modifications, and compatibility with sample types.
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