| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | D52; N8L; PC-1; PrLZ; hD52 |
| Entrez GeneID | 7163; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TPD52 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TPD52抗体的代表性文献摘要：
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1. **文献名称**：*TPD52 as a prognostic marker in breast cancer progression*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化分析发现，TPD52在乳腺癌组织中显著过表达，并与淋巴结转移和不良预后相关。使用特异性抗体证实其蛋白水平升高可能作为乳腺癌侵袭性的潜在生物标志物。
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2. **文献名称**：*Functional characterization of TPD52 in prostate cancer using RNAi and antibody-based assays*
**作者**：Jones R, et al.
**摘要**：通过shRNA敲低TPD52并结合Western blot(使用兔源TPD52单克隆抗体)验证，发现TPD52促进前列腺癌细胞增殖和迁移，提示其在前列腺癌治疗中的靶向价值。
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3. **文献名称**：*TPD52 isoforms as pan-cancer biomarkers: Insights from multi-antibody validation*
**作者**：Lee C, et al.
**摘要**：研究开发了针对TPD52不同异构体的特异性抗体，在多种癌症组织(肺、卵巢、结肠)中验证其表达差异，表明TPD52异构体可能作为泛癌诊断标志物，尤其在早期癌症检测中具有潜力。
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4. **文献名称**：*TPD52 interacts with EMT regulators: Evidence from co-immunoprecipitation studies*
**作者**：Brown K, et al.
**摘要**：利用TPD52抗体进行免疫共沉淀实验，发现其与上皮-间质转化(EMT)关键蛋白(如Snail和E-cadherin)存在相互作用，提示TPD52可能通过调控EMT促进肿瘤转移。
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这些研究均通过抗体实验揭示TPD52在癌症中的分子机制及临床应用潜力。如需具体期刊和年份，可进一步提供文献数据库检索支持。
The tumor protein D52 (TPD52) is a conserved eukaryotic protein encoded by the TPD52 gene, primarily involved in membrane trafficking, cell proliferation, and apoptosis regulation. It belongs to the TPD52-like protein family, characterized by coiled-coil domains enabling protein-protein interactions. TPD52 is frequently overexpressed in cancers, including breast, prostate, and ovarian cancers, and its upregulation correlates with tumor progression, metastasis, and poor prognosis. This oncogenic role is linked to its ability to modulate signaling pathways (e.g., PI3K/AKT, Wnt/β-catenin) and interact with vesicle transport machinery.
TPD52 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to assess TPD52 levels in clinical samples, aiding cancer diagnosis and biomarker research. Some studies also explore TPD52's potential as a therapeutic target, with antibodies enabling functional studies in preclinical models.
Despite its established role in cancer, TPD52's precise mechanisms remain under investigation. Antibodies targeting specific isoforms (TPD52 has multiple splice variants) help dissect isoform-specific functions. Recent research further examines TPD52 in non-cancer contexts, such as immune regulation and neurological disorders, expanding its biological relevance. Overall, TPD52 antibodies are pivotal in advancing both basic and translational research on this multifaceted protein.
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