Rabbit Polyclonal SETMAR Antibody

The SETMAR antibody is a research tool designed to detect the SETMAR protein, a primate-specific enzyme resulting from the fusion of a SET (Su(var)3-9. Enhancer-of-zeste, Trithorax) domain and a transposase-derived MAR (Methanothermobacter thermautotrophicus) domain. This chimeric gene emerged ~50 million years ago in anthropoid primates through a retrotransposition event, where the SET gene merged with a mariner-family transposase. SETMAR functions as a histone methyltransferase (via its SET domain) and binds DNA double-strand breaks (via its MAR domain), playing roles in DNA repair, transcription regulation, and genome stability. Antibodies targeting SETMAR are used to study its expression patterns, subcellular localization, and interactions in cellular processes. Research links SETMAR to cancer progression, neurodevelopmental disorders, and viral defense mechanisms. Its overexpression in certain tumors has sparked interest in its potential as a therapeutic target. Commercial SETMAR antibodies are typically validated for applications like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), though cross-reactivity with ancestral SET proteins remains a technical consideration. Studies using these antibodies contribute to understanding primate-specific genomic adaptations and disease mechanisms.