| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HNUDC; MNUDC; NPD011 |
| Entrez GeneID | 10726; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Fusion protein of human NUDC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NUDC抗体的3篇文献参考(内容基于真实研究领域，但文献标题和作者为模拟示例)：
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1. **文献名称**：*NUDC Expression in Human Tumors: A Potential Biomarker for Cancer Progression*
**作者**：Li, X. et al.
**摘要**：该研究通过免疫组化(使用NUDC特异性抗体)分析了NUDC在多种实体瘤中的表达水平，发现其在肺癌、结直肠癌中显著上调，且与患者生存率负相关，提示NUDC可能作为癌症预后标志物。
2. **文献名称**：*Role of NUDC in Mitotic Spindle Regulation: Insights from Antibody-mediated Knockdown*
**作者**：Yamamoto, K. et al.
**摘要**：利用NUDC抗体进行功能阻断实验，证明NUDC通过调控微管稳定性影响有丝分裂纺锤体形成，其缺失导致染色体分离异常，为肿瘤治疗提供潜在靶点。
3. **文献名称**：*Development of a High-Specificity Monoclonal Antibody Against NUDC for Diagnostic Applications*
**作者**：Chen, J. et al.
**摘要**：报道了一种新型NUDC单克隆抗体的开发与验证，通过ELISA和Western blot证实其高亲和力与特异性，成功应用于脑胶质瘤组织样本的病理检测。
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**说明**：上述文献为领域内典型研究方向示例，实际文献需通过PubMed或Web of Science以关键词“NUDC antibody”、“NUDC cancer”等检索获取。
NUDC (Nuclear Distribution Protein C) is a highly conserved protein involved in regulating microtubule dynamics and mitotic processes, particularly during cell division. It plays a critical role in ensuring proper chromosome segregation by interacting with components of the dynein motor complex and the LIS1 (lissencephaly-1) protein. This interaction facilitates spindle organization, nuclear positioning, and intracellular transport, which are essential for maintaining genomic stability. Dysregulation of NUDC has been linked to mitotic errors, aneuploidy, and developmental disorders, including neurological conditions like lissencephaly and microcephaly.
NUDC antibodies are essential tools for studying these mechanisms in biomedical research. They enable the detection and localization of NUDC in cells and tissues through techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers use these antibodies to explore NUDC’s involvement in cancer progression, where its overexpression is observed in certain tumors and correlated with poor prognosis. Additionally, NUDC antibodies help elucidate its role in neurodevelopment, particularly in neuronal migration and cortical organization. Recent studies also investigate its potential as a therapeutic target for disrupting pathological processes like tumor growth or neurodevelopmental defects. As NUDC’s functions intersect with critical cellular pathways, its antibodies remain pivotal in advancing understanding of cell cycle regulation, cytoskeletal dynamics, and disease pathogenesis.
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