| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RRS1; KIAA0112; RRR; Ribosome biogenesis regulatory protein homolog |
| Entrez GeneID | 23212; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human RRS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与RRS1抗体相关的文献示例(内容为模拟概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *RRS1. a plant immune receptor, interacts with and is stabilized by its partner RPS5 in Arabidopsis*
**作者**: Williams SJ et al.
**摘要**: 本研究利用RRS1特异性抗体验证了拟南芥中RRS1蛋白与RPS5的相互作用，发现RRS1的稳定性依赖于RPS5.Western blot和免疫共沉淀实验表明，RPS5缺失导致RRS1蛋白降解加速，揭示了二者在植物免疫中的协同调控机制。
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2. **文献名称**: *RRS1 Antibody-Based Detection of Ribosome Biogenesis Defects in Human Cancer Cells*
**作者**: Li H et al.
**摘要**: 通过开发高特异性RRS1单克隆抗体，研究团队发现RRS1在结直肠癌细胞核仁中异常高表达。免疫组化分析显示，RRS1水平与患者预后不良相关，提示其可能作为核糖体合成失调的癌症标志物。
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3. **文献名称**: *Functional Characterization of RRS1 in Rice Innate Immunity Using CRISPR Mutants and Polyclonal Antibodies*
**作者**: Chen Y et al.
**摘要**: 研究通过制备水稻RRS1多克隆抗体，结合CRISPR突变体，证明RRS1通过调控水杨酸信号通路参与抗稻瘟病反应。免疫荧光显示病原菌侵染后RRS1向细胞核迁移，表明其动态定位与抗病功能相关。
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如需具体文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词："RRS1 antibody"、"RRS1 immune response" 或结合研究领域(如植物/癌症)筛选。
The RRS1 (Ribosome biogenesis regulator homolog) antibody targets the RRS1 protein, a critical factor in ribosome biosynthesis. RRS1 is evolutionarily conserved and primarily localizes to the nucleolus, where it plays a key role in rRNA processing and ribosomal subunit assembly. Studies suggest that RRS1 interacts with ribosomal proteins and other biogenesis factors, facilitating the maturation of 60S ribosomal subunits. Dysregulation of RRS1 has been linked to ribosomopathies and cancer, as its overexpression is observed in malignancies like colorectal and breast cancer, potentially driving uncontrolled cell proliferation.
The RRS1 antibody is widely used in molecular biology research to investigate ribosome assembly mechanisms, nucleolar dynamics, and cellular stress responses. It serves as a tool for detecting RRS1 expression via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Recent studies also explore its role in p53-dependent pathways, where RRS1 depletion triggers nucleolar stress, activating p53 and inducing cell cycle arrest. Despite its significance, the precise molecular functions of RRS1 remain under investigation, particularly its regulatory interactions during ribosome biogenesis and its implications in disease pathogenesis. This antibody thus provides critical insights into both basic ribosome biology and therapeutic targeting of ribosome-related disorders.
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