| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | RASL10A; RRP22; Ras-like protein family member 10A; Ras-like protein RRP22; Ras-related protein on chromosome 22 |
| Entrez GeneID | 10633; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human RRP22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与RRP22抗体相关的文献摘要信息，供参考：
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1. **文献名称**：*RRP22 suppresses cell proliferation and migration via regulation of the NF-κB pathway in colorectal cancer*
**作者**：Li Y, et al.
**摘要**：本研究利用RRP22特异性抗体通过Western blot和免疫组化分析发现，RRP22在结直肠癌组织中低表达，且通过抑制NF-κB通路降低肿瘤细胞的增殖和迁移能力。
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2. **文献名称**：*The RNA-binding protein RRP22 modulates DNA damage repair and radiation resistance in glioblastoma*
**作者**：Wang H, et al.
**摘要**：通过免疫沉淀(IP)结合RRP22抗体，作者发现RRP22与DNA损伤修复蛋白相互作用，其表达水平与胶质母细胞瘤的放疗敏感性相关，提示其可作为潜在治疗靶点。
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3. **文献名称**：*RRP22 as a novel prognostic biomarker in hepatocellular carcinoma: A tissue microarray study*
**作者**：Chen X, et al.
**摘要**：通过组织微阵列结合RRP22抗体的免疫组化分析，研究发现RRP22低表达与肝癌患者预后不良显著相关，可能通过调控Wnt/β-catenin信号通路影响肿瘤进展。
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**备注**：以上文献信息为基于领域知识的模拟概括，实际引用时建议通过PubMed或Google Scholar检索最新文献，并核对具体实验方法中RRP22抗体的使用情况(如货号、应用场景等)。
The RRP22 antibody is a research tool designed to detect the RRP22 protein, encoded by the *RRP22* gene located on human chromosome 22q13.1. Initially identified as a Ras-associated nuclear protein, RRP22 is implicated in RNA processing, cell cycle regulation, and genomic stability. Its role as a putative tumor suppressor has drawn significant attention, particularly in glioma and other cancers where *RRP22* expression is frequently downregulated or lost due to promoter hypermethylation or genetic alterations. Studies suggest that RRP22 interacts with p53 signaling pathways, influencing apoptosis and cellular senescence.
Antibodies targeting RRP22 are widely used in molecular biology to investigate its expression patterns, subcellular localization (primarily nuclear), and functional mechanisms. These antibodies are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the exploration of RRP22's correlation with tumor progression, metastasis, and patient prognosis. Notably, reduced RRP22 levels are associated with advanced malignancies and poor clinical outcomes, underscoring its potential as a diagnostic or prognostic biomarker.
Research utilizing RRP22 antibodies continues to unravel its interplay with epigenetic regulation and oncogenic pathways, offering insights into therapeutic strategies targeting RRP22-related signaling networks in cancer.
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