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Rabbit Polyclonal RECS1 Antibody

  • 中文名: RECS1抗体
  • 别    名: TMBIM1; LFG3; RECS1; PP1201; PSEC0158; Protein lifeguard 3; Protein RECS1 homolog; Transmembrane BAX inhibitor motif-containing protein 1
货号: IPDX43252
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/40000 Human,Mouse,Rat

产品详情

AliasesTMBIM1; LFG3; RECS1; PP1201; PSEC0158; Protein lifeguard 3; Protein RECS1 homolog; Transmembrane BAX inhibitor motif-containing protein 1
Entrez GeneID64114;
WB Predicted band size35kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from the C-terminal region of human RECS1.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于RECS1抗体的虚构参考文献示例(注:内容为模拟创作,非真实文献):

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1. **文献名称**:*RECS1 is a novel regulator of mitochondrial apoptosis and interacts with Bcl-2 family proteins*

**作者**:Yamada T, et al.

**摘要**:本研究利用RECS1特异性抗体,发现RECS1蛋白通过调控线粒体膜通透性参与细胞凋亡,并与Bcl-2家族蛋白(如Bax和Bcl-xL)直接相互作用,提示其在癌症治疗中的潜在靶点作用。

2. **文献名称**:*RECS1 antibody reveals its overexpression in lung adenocarcinoma and prognostic significance*

**作者**:Chen L, et al.

**摘要**:通过免疫组化(RECS1抗体)和生存分析,发现RECS1在肺腺癌组织中高表达,且与患者不良预后相关,提示其可作为肿瘤诊断和分层的生物标志物。

3. **文献名称**:*RECS1 deficiency impairs cardiac development via dysregulated autophagy in zebrafish*

**作者**:Smith J, et al.

**摘要**:在斑马鱼模型中,RECS1抗体用于蛋白定位分析,结果表明RECS1缺失导致心脏发育异常,其机制与自噬通路失调及心肌细胞增殖缺陷相关。

4. **文献名称**:*Structural characterization of RECS1 protein complex using epitope-specific antibodies*

**作者**:Gómez-Ruiz S, et al.

**摘要**:通过表位特异性RECS1抗体结合质谱技术,解析了RECS1蛋白复合物的三维结构,揭示了其与DNA修复蛋白BRCA1的功能关联,为遗传性疾病研究提供新方向。

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如需真实文献,建议通过PubMed或Web of Science检索“RECS1 antibody”或“RECS1 protein function”获取。

背景信息

RECS1 (Regulator of sister chromatid separation 1), also known as stromal antigen 3 (STAG3) or SYCP2. is a protein involved in chromosome cohesion and segregation during cell division. It plays a critical role in maintaining genomic stability by ensuring proper sister chromatid separation in mitosis and meiosis. The RECS1 gene encodes a component of the cohesin complex, which mediates chromatid cohesion and facilitates DNA repair. Dysregulation of RECS1 has been linked to chromosomal instability disorders, infertility, and cancer progression. Antibodies targeting RECS1 are essential tools for studying its expression, localization, and function in cellular processes. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate RECS1's role in gametogenesis, tumorigenesis, and response to DNA damage. Research utilizing RECS1 antibodies has highlighted its potential as a biomarker in reproductive disorders and cancers, particularly those with defective DNA repair mechanisms. Recent studies also explore its interaction with other cohesin subunits, offering insights into novel therapeutic strategies targeting chromosomal instability in diseases.

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