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Rabbit Polyclonal Rab34 Antibody

  • 中文名： Rab 34抗体
  • 别    名： RAB34; RAB39; RAH; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah
货号: IPDX43251
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000 Human,Mouse,Rat

产品详情

AliasesRAB34; RAB39; RAH; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah
Entrez GeneID83871;
WB Predicted band size29kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from the C-terminal region of human Rab 34.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于Rab34抗体的3篇参考文献的简要信息(注：以下内容为模拟示例，实际文献需根据具体数据库检索确认)：

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1. **文献名称**: "Rab34 regulates cell migration and invasion by modulating focal adhesion dynamics"

**作者**: Smith A, et al.

**摘要**: 研究通过Rab34抗体进行免疫印迹和免疫荧光分析，发现Rab34通过调控粘着斑的稳定性影响肿瘤细胞的迁移和侵袭能力，揭示其在癌症转移中的作用机制。

2. **文献名称**: "Rab34 interacts with BORC to regulate lysosomal positioning"

**作者**: Chen L, et al.

**摘要**: 利用Rab34特异性抗体进行免疫沉淀和共定位实验，证明Rab34与BORC复合物互作，参与溶酶体在细胞内的定位及功能调控，影响自噬过程。

3. **文献名称**: "Expression profiling of Rab GTPases in colorectal cancer using a Rab34-specific antibody"

**作者**: Wang Y, et al.

**摘要**: 通过Rab34抗体的免疫组化分析，发现Rab34在结直肠癌组织中高表达，并与患者预后不良相关，提示其作为潜在生物标志物的可能性。

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如需具体文献，建议通过PubMed或Google Scholar以“Rab34 antibody”为关键词检索最新研究。

背景信息

Rab34 antibody is a tool used to detect Rab34. a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking and membrane dynamics. Rab proteins are critical for maintaining cellular compartmentalization by controlling vesicle formation, transport, and fusion. Rab34. specifically, localizes to the Golgi apparatus and late endosomes, and has been implicated in processes like lysosomal positioning, ciliogenesis, and autophagy. Its role in directing vesicle movement along microtubules highlights its importance in cellular homeostasis. Dysregulation of Rab34 is linked to pathological conditions, including cancer, neurodegenerative disorders, and ciliopathies. For example, Rab34 overexpression in certain tumors correlates with enhanced invasiveness and metastasis, suggesting its potential as a therapeutic target. The Rab34 antibody enables researchers to study its expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Both polyclonal and monoclonal variants are available, typically raised in rabbits or mice. Validating antibody specificity is crucial, as cross-reactivity with other Rab isoforms can occur. Recent studies also explore Rab34’s role in immune responses and organelle stress, expanding its relevance in biomedical research. Overall, Rab34 antibodies are essential for dissecting the molecular mechanisms of intracellular trafficking and disease pathogenesis.

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