Rabbit Polyclonal Rab34 Antibody

Rab34 antibody is a tool used to detect Rab34. a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking and membrane dynamics. Rab proteins are critical for maintaining cellular compartmentalization by controlling vesicle formation, transport, and fusion. Rab34. specifically, localizes to the Golgi apparatus and late endosomes, and has been implicated in processes like lysosomal positioning, ciliogenesis, and autophagy. Its role in directing vesicle movement along microtubules highlights its importance in cellular homeostasis. Dysregulation of Rab34 is linked to pathological conditions, including cancer, neurodegenerative disorders, and ciliopathies. For example, Rab34 overexpression in certain tumors correlates with enhanced invasiveness and metastasis, suggesting its potential as a therapeutic target. The Rab34 antibody enables researchers to study its expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Both polyclonal and monoclonal variants are available, typically raised in rabbits or mice. Validating antibody specificity is crucial, as cross-reactivity with other Rab isoforms can occur. Recent studies also explore Rab34’s role in immune responses and organelle stress, expanding its relevance in biomedical research. Overall, Rab34 antibodies are essential for dissecting the molecular mechanisms of intracellular trafficking and disease pathogenesis.