Rabbit Polyclonal NAB2 Antibody

The NAB2 (NGFI-A-binding protein 2) antibody is a tool used to detect and study the NAB2 protein, a transcriptional regulator that interacts with early growth response (EGR) family proteins, particularly EGR1. NAB2 functions as a co-repressor or co-activator, modulating EGR1-mediated gene expression involved in cell proliferation, differentiation, and apoptosis. Dysregulation of NAB2 is linked to pathological conditions, most notably in cancer. For example, a recurrent NAB2-STAT6 gene fusion, resulting from chromosomal rearrangement, is a hallmark of solitary fibrous tumors (SFTs). Antibodies targeting NAB2 help identify this fusion protein in diagnostic workflows. In neuroscience, NAB2 is implicated in synaptic plasticity and neuronal development, with studies exploring its role in neurodegenerative diseases. Researchers use NAB2 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in tissues or cell lines. Commercially available antibodies are often validated for specificity against epitopes in the N-terminal or C-terminal regions, depending on research needs. Understanding NAB2's dual roles in oncogenesis and neural function underscores its significance as both a biomarker and a therapeutic target.