首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal NAB2 Antibody

  • 中文名： NAB2抗体
  • 别    名： NAB2; MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
货号: IPDX43196
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesNAB2; MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
Entrez GeneID4665;
WB Predicted band size56kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from the Internal region of human NAB2.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

+ +

参考文献

以下是3篇涉及NAB2抗体的文献摘要示例(注：文献为虚拟示例，实际引用需核查原文)：

---

1. **文献名称**：*NAB2-STAT6 Fusion Gene and Protein Expression in Solitary Fibrous Tumors*

**作者**：Doyle LA, et al.

**摘要**：研究通过免疫组化(使用NAB2特异性抗体)和分子分析，揭示了NAB2-STAT6融合基因在孤立性纤维性肿瘤中的诊断价值，证实NAB2抗体可作为该肿瘤的可靠生物标志物。

---

2. **文献名称**：*Transcriptional Repression by NAB2 in Cancer Cell Proliferation*

**作者**：Russo MW, et al.

**摘要**：利用NAB2抗体进行Western blot和染色质免疫沉淀(ChIP)，证明NAB2通过抑制EGR1靶基因调控肿瘤细胞增殖，为癌症治疗提供潜在靶点。

---

3. **文献名称**：*NAB2 Antibody Localization in Glioblastoma and Neural Development*

**作者**：Verstappen G, et al.

**摘要**：通过免疫荧光和NAB2抗体的组织特异性标记，研究发现NAB2在胶质母细胞瘤中异常高表达，并与神经发育中的转录调控网络相关。

---

(注：以上文献信息为模拟生成，实际研究中请通过PubMed或学术数据库检索真实文献。)

背景信息

The NAB2 (NGFI-A-binding protein 2) antibody is a tool used to detect and study the NAB2 protein, a transcriptional regulator that interacts with early growth response (EGR) family proteins, particularly EGR1. NAB2 functions as a co-repressor or co-activator, modulating EGR1-mediated gene expression involved in cell proliferation, differentiation, and apoptosis. Dysregulation of NAB2 is linked to pathological conditions, most notably in cancer. For example, a recurrent NAB2-STAT6 gene fusion, resulting from chromosomal rearrangement, is a hallmark of solitary fibrous tumors (SFTs). Antibodies targeting NAB2 help identify this fusion protein in diagnostic workflows. In neuroscience, NAB2 is implicated in synaptic plasticity and neuronal development, with studies exploring its role in neurodegenerative diseases. Researchers use NAB2 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in tissues or cell lines. Commercially available antibodies are often validated for specificity against epitopes in the N-terminal or C-terminal regions, depending on research needs. Understanding NAB2's dual roles in oncogenesis and neural function underscores its significance as both a biomarker and a therapeutic target.

客户数据及评论

折叠内容

大包装询价

×