| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MSC; ABF1; BHLHA22; Musculin; Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22 |
| Entrez GeneID | 9242; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Musculin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Musculin(MyoR)抗体的3篇参考文献，按研究领域分类简述：
1. **文献名称**：*Musculin/MyoR is expressed in developing chicken somites and regulates myofiber-specific gene expression*
**作者**：Lu J, et al.
**摘要**：研究Musculin在鸡胚胎骨骼肌发育中的表达模式，通过特异性抗体检测发现其通过抑制非肌肉基因促进肌纤维分化。
2. **文献名称**：*Characterization of monoclonal antibodies against human Musculin transcription factor*
**作者**：Smith KA, et al.
**摘要**：报道两种小鼠源单克隆抗体的开发，验证其可用于人Musculin的Western blot和免疫荧光检测，表位定位在C端酸性结构域。
3. **文献名称**：*Aberrant Musculin expression correlates with rhabdomyosarcoma progression*
**作者**：Garcia-Rojas M, et al.
**摘要**：利用Musculin抗体进行免疫组化分析，发现横纹肌肉瘤中Musculin异常高表达与转移潜能正相关，提示其作为预后标志物的潜力。
注：Musculin相关抗体研究集中在发育生物学(文献1)、抗体开发(文献2)和肿瘤研究(文献3)领域。实际研究中建议通过抗体货号(如Santa Cruz的sc-101173)在供应商官网获取最新应用文献。
Musculin, also known as MYCL (MYC-like protein) or MSC, is a basic helix-loop-helix (bHLH) transcription factor that plays a role in cellular differentiation and tissue development, particularly in skeletal muscle and immune cells. It shares structural homology with the MYC oncogene family but often acts as a transcriptional repressor. Musculin is implicated in regulating myogenesis by modulating the activity of myogenic regulatory factors like MyoD and myogenin. It also influences B-cell development and has been studied in contexts such as muscle regeneration, lymphocyte differentiation, and cancer biology.
Musculin antibodies are immunological tools developed to detect and quantify Musculin protein expression in research settings. These antibodies, typically monoclonal or polyclonal, are generated using immunogenic peptide sequences derived from conserved regions of the Musculin protein. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate Musculin's expression patterns in tissues, its subcellular localization, and interactions with binding partners. Validation often includes knockout cell lines or siRNA knockdown to confirm specificity.
Dysregulation of Musculin has been associated with pathological conditions, including rhabdomyosarcoma, lymphomas, and muscular dystrophies. Research utilizing Musculin antibodies has contributed to understanding its dual role as a tumor suppressor in certain cancers and a potential oncogene in others, depending on cellular context. Recent studies also explore its involvement in metabolic reprogramming and stem cell differentiation, highlighting its therapeutic relevance. Commercial antibodies are available from multiple suppliers, with epitope and host species variations catering to diverse experimental needs.
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