| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neurogenic differentiation factor 1; NEUROD1; NEUROD; |
| Entrez GeneID | 4760; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Neuro D (Ab-274)抗体的虚构示例参考文献(实际文献需通过学术数据库查询)：
1. **标题**: "NeuroD1 Expression in Neural Development: Insights from a Novel Antibody (Ab-274)"
**作者**: Smith J, et al.
**摘要**: 研究使用Ab-274抗体通过免疫组化和Western blot分析NeuroD1在小鼠胚胎神经发育中的表达模式，证实其在神经元分化中的关键作用。
2. **标题**: "Validation of Neuro D Antibody (Ab-274) in Human Brain Tissue"
**作者**: Lee H, et al.
**摘要**: 验证Ab-274抗体在人类脑组织中的特异性，通过免疫荧光和流式细胞术证明其对成熟神经元标记物NeuroD的高效检测能力。
3. **标题**: "Role of NeuroD in Pancreatic β-Cell Differentiation: A Study Using Ab-274"
**作者**: Chen R, et al.
**摘要**: 利用Ab-274抗体研究NeuroD在胰腺β细胞分化中的调控机制，发现其缺失导致胰岛素分泌异常，提示与糖尿病相关。
4. **标题**: "Comparative Analysis of NeuroD Antibodies in Zebrafish Models"
**作者**: Garcia M, et al.
**摘要**: 比较Ab-274与其他商业抗体在斑马鱼神经发育研究中的性能，显示Ab-274在活体成像中的低背景和高信噪比优势。
**备注**：以上内容为示例，实际文献需通过PubMed、Google Scholar或抗体供应商(如Abcam、Cell Signaling Technology)提供的产品引用文献查询。建议结合具体实验背景筛选相关研究。
**Background of Neuro D (Ab-274) Antibody**
Neuro D, also known as Beta2. is a basic helix-loop-helix (bHLH) transcription factor critical in neuronal differentiation and development. It plays a pivotal role in regulating neurogenesis, particularly in the formation of the hippocampus, cerebellum, and retina, as well as in pancreatic β-cell maturation. Neuro D promotes cell cycle exit and activates genes essential for terminal neuronal differentiation, making it a key marker for studying neurodevelopmental processes and neurodegenerative diseases.
The Neuro D (Ab-274) antibody is a monoclonal antibody designed to specifically recognize and bind to Neuro D proteins in various experimental applications, including immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF). Its high specificity ensures reliable detection of endogenous Neuro D expression in tissues and cell lines, aiding research on neural stem cells, brain development, and diseases like Alzheimer’s or diabetes.
Developed using immunogens targeting conserved regions of Neuro D across species, Ab-274 exhibits cross-reactivity in humans, mice, and rats, facilitating translational studies. Its validation in multiple assays underscores its utility in both basic and applied research, particularly in exploring mechanisms of neuronal fate determination, synaptic plasticity, and regenerative medicine. By enabling precise tracking of Neuro D expression, this antibody serves as a vital tool for unraveling the molecular underpinnings of neurobiology and related pathologies.
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