| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cyclin D2; G1/S-specific cyclin D2; |
| Entrez GeneID | 894; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Cyclin D2 (Ab-280)抗体的3篇参考文献示例(注：以下内容为模拟示例，具体文献需根据实际检索结果调整)：
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1. **文献名称**: "Cyclin D2 is a critical target of β-catenin in melanocyte transformation"
**作者**: Solvason, N., et al.
**摘要**: 本研究利用Cyclin D2 (Ab-280)抗体通过免疫印迹和免疫组化分析，揭示了β-catenin信号通路通过上调Cyclin D2表达促进黑色素瘤细胞增殖的机制。
2. **文献名称**: "Cyclin D2 deficiency alters cerebellar development and leads to hyperactivity in mice"
**作者**: Sicinski, P., et al.
**摘要**: 文章通过Cyclin D2 (Ab-280)抗体的免疫荧光染色，发现Cyclin D2缺失导致小鼠小脑颗粒细胞分化异常，并引发行为学异常，为神经发育疾病提供了新见解。
3. **文献名称**: "Aberrant Cyclin D2 expression in B-cell malignancies correlates with disease progression"
**作者**: Hosokawa, Y., et al.
**摘要**: 该研究使用Cyclin D2 (Ab-280)抗体检测B细胞淋巴瘤样本，发现Cyclin D2过表达与患者预后不良显著相关，提示其作为潜在治疗靶点的价值。
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如需获取真实文献，建议通过PubMed或Google Scholar检索关键词“Cyclin D2 antibody Ab-280”或联系抗体供应商(如CST、Abcam)提供的引用文献列表。
Cyclin D2 (Ab-280) antibody is a monoclonal antibody specifically designed to detect Cyclin D2. a key regulatory protein involved in cell cycle progression. Cyclin D2 belongs to the D-type cyclin family, which plays a critical role in transitioning cells from the G1 phase to the S phase by interacting with cyclin-dependent kinases (CDKs), particularly CDK4 and CDK6. This interaction promotes phosphorylation of retinoblastoma (Rb) protein, facilitating the release of transcription factors necessary for DNA replication. Dysregulation of Cyclin D2 has been implicated in various cancers, including leukemias, lymphomas, and solid tumors, making it a significant biomarker for oncological research.
The Ab-280 clone targets an epitope near the N-terminal region of human Cyclin D2 (around amino acid residue 280), enabling specific recognition in assays such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP). Developed in mouse hosts, this antibody is validated for reactivity with human, mouse, and rat samples, though species-specific cross-reactivity should be confirmed experimentally. Its applications extend to studying cell cycle mechanisms, cancer biology, and tissue-specific expression patterns. Researchers often use it to explore Cyclin D2's role in cellular proliferation, differentiation, and apoptosis, as well as its interplay with oncogenic signaling pathways. Proper controls, including knockout or knockdown validation, are recommended to ensure specificity in experimental settings.
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