| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CEPTRL2; claudin 7; claudin 9; claudin-1; claudin-7 |
| Entrez GeneID | 1366; |
| WB Predicted band size | 32kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human Claudin 7 around the phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Claudin 7 (Ab-210)抗体的3篇参考文献示例(注：文献信息为示例性概括，具体引用需核实原始文献)：
1. **文献名称**：*"Downregulation of Claudin-7 in Colorectal Cancer Correlates with Invasive Phenotype"*
**作者**：Dhawan, P. et al.
**摘要**：通过免疫组化和Western blot(使用Claudin 7 Ab-210抗体)发现，Claudin-7在结直肠癌中表达显著下调，其缺失通过激活EGFR/ERK通路促进肿瘤细胞侵袭和转移。
2. **文献名称**：*"Claudin-7 Expression in Breast Cancer: A Biomarker for Prognosis"*
**作者**：Tokes, A.M. et al.
**摘要**：利用Claudin 7 (Ab-210)抗体进行组织微阵列分析，发现Claudin-7在三阴性乳腺癌中低表达，与患者不良预后和远处转移风险增加相关。
3. **文献名称**：*"Role of Claudin-7 in Epidermal Barrier Formation and Differentiation"*
**作者**：Hewitt, K.J. et al.
**摘要**：通过基因敲除小鼠模型及Western blot(抗体Ab-210)证实，Claudin-7对表皮紧密连接完整性至关重要，其缺失导致皮肤屏障功能障碍和异常角化。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“Claudin 7 antibody Ab-210”或联系抗体供应商获取引用列表。
Claudin 7 (CLDN7) is a key component of tight junction complexes, which regulate paracellular permeability and maintain cell polarity in epithelial and endothelial tissues. As a member of the claudin family, it plays a critical role in barrier formation, cell adhesion, and signal transduction. Dysregulation of CLDN7 has been implicated in various pathologies, including cancer progression, inflammatory diseases, and tissue fibrosis. In cancer, CLDN7 expression is often altered, with studies linking its downregulation to increased invasiveness in certain carcinomas (e.g., breast, colorectal) or overexpression in others (e.g., lung adenocarcinoma), suggesting context-dependent roles in tumorigenesis.
The Claudin 7 (Ab-210) antibody is a monoclonal antibody raised against a specific epitope of human CLDN7. commonly used to detect the protein’s expression and localization in research applications. It has been validated in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), demonstrating specificity for the ~27 kDa CLDN7 protein. Researchers utilize this antibody to investigate tissue-specific CLDN7 distribution, its relationship to epithelial-mesenchymal transition (EMT), and potential as a diagnostic or prognostic biomarker. Its reliability in formalin-fixed, paraffin-embedded (FFPE) samples makes it particularly valuable for retrospective clinical studies. Ongoing research focuses on clarifying CLDN7’s dual roles in tumor suppression and promotion, as well as its therapeutic potential in targeting epithelial barrier dysfunction.
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