| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C; |
| Entrez GeneID | 4208; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized non-phosphopeptide derived from human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MEF2C (Ab-396)抗体的3篇示例参考文献(注：以下内容为示例性概括，非真实文献)：
1. **文献名称**: "MEF2C regulates neurodevelopment through chromatin remodeling in neural stem cells"
**作者**: Smith A, et al.
**摘要**: 本研究利用MEF2C (Ab-396)抗体通过染色质免疫沉淀(ChIP)技术，揭示了MEF2C在神经干细胞分化过程中通过结合特定基因启动子调控神经发育的分子机制。
2. **文献名称**: "Cardiac hypertrophy driven by MEF2C transcriptional activation requires phosphorylation at Ser396"
**作者**: Lee J, et al.
**摘要**: 通过Western blot和免疫荧光实验(使用MEF2C Ab-396抗体)，证实MEF2C在心脏肥大中的关键作用，其Ser396位点的磷酸化是激活下游靶基因的必要条件。
3. **文献名称**: "MEF2C ablation in myeloid cells promotes tumor progression via immune suppression"
**作者**: Chen H, et al.
**摘要**: 研究使用MEF2C (Ab-396)抗体进行免疫组化分析，发现骨髓细胞中MEF2C缺失通过调控免疫微环境促进肿瘤生长，为癌症治疗提供新靶点。
如需真实文献，建议通过PubMed或Google Scholar检索抗体编号“Ab-396”及“MEF2C”关键词，或参考抗体供应商(如CST、Abcam)官网提供的引用文献。
The MEF2C (Ab-396) antibody is a monoclonal or polyclonal reagent designed to specifically recognize the Myocyte Enhancer Factor 2C (MEF2C) protein, a transcription factor belonging to the MEF2 family. MEF2C plays critical roles in cellular differentiation, muscle development, and neurogenesis, regulating the expression of genes involved in these processes. The antibody, often identified by the clone number or catalog designation "Ab-396." is commonly used in research applications such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP).
MEF2C is highly expressed in cardiac, skeletal muscle, and neural tissues, where it interacts with cofactors like histone deacetylases (HDACs) and other transcriptional regulators. Dysregulation of MEF2C has been linked to developmental disorders, neurological conditions, and cardiovascular diseases. The Ab-396 antibody typically targets a specific epitope or post-translational modification site (e.g., phosphorylation) within the MEF2C protein, aiding in studies of its activity, localization, or interaction networks.
Researchers utilize this antibody to explore MEF2C's role in cellular pathways, disease mechanisms, or developmental biology. Validation data, including species reactivity (e.g., human, mouse, rat) and specificity, are crucial for experimental reliability. Proper controls, such as knockout or knockdown samples, are recommended to confirm antibody performance. Overall, MEF2C (Ab-396) serves as a vital tool for dissecting the molecular functions of MEF2C in health and disease.
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