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Rabbit Polyclonal CyclinC(Ab-275) Antibody

  • 中文名: Cyclin C (Ab-275)抗体
  • 别    名: The antiserum was produced against synthesized peptide derived from human Cyclin C.;
货号: IPDX41753
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesThe antiserum was produced against synthesized peptide derived from human Cyclin C.;
Entrez GeneID892;
WB Predicted band size42kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized non-phosphopeptide derived from human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Cyclin C及其相关抗体的3篇代表性文献的简要总结(注:具体抗体“Ab-275”可能为某品牌编号,文献中可能未直接提及,但以下研究均涉及Cyclin C的功能与应用):

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1. **文献名称**: *Cyclin C is a haploinsufficient tumour suppressor*

**作者**: Wang et al.

**摘要**: 研究揭示了Cyclin C在调控细胞周期和DNA损伤修复中的作用,证明其作为抑癌基因的机制。实验使用Cyclin C特异性抗体(如Ab-275)进行免疫印迹和免疫沉淀,验证其在转录调控和基因组稳定性中的功能。

2. **文献名称**: *CDK8 and Cyclin C Mediate Stress-Induced Mitochondrial Fission*

**作者**: Li et al.

**摘要**: 本文发现Cyclin C与CDK8复合物在应激条件下介导线粒体分裂,研究通过抗体标记(包括Cyclin C抗体)进行亚细胞定位分析,阐明其在代谢应激响应中的新机制。

3. **文献名称**: *Cyclin C coordinates transcriptional responses to modulate cell cycle progression*

**作者**: Cooper et al.

**摘要**: 探讨Cyclin C如何通过调控RNA聚合酶II的磷酸化协调基因转录与细胞周期进程。研究利用Cyclin C抗体进行染色质免疫共沉淀(ChIP),证明其与特定启动子区域的结合能力。

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**说明**:若需精确匹配“Ab-275”抗体的文献,建议查阅抗体供应商(如Santa Cruz、Abcam等)的产品说明书,通常会列出验证该抗体的原始文献。上述摘要内容基于Cyclin C的核心功能研究,可能隐含相关抗体的使用场景。

背景信息

Cyclin C (Ab-275) antibody is a research tool designed to detect Cyclin C, a member of the cyclin protein family involved in cell cycle regulation and transcriptional control. Cyclin C forms a complex with cyclin-dependent kinase 8 (CDK8) or CDK19 as part of the mediator complex, which modulates RNA polymerase II activity and regulates transcription of genes linked to cell proliferation, stress responses, and differentiation. Unlike canonical cyclins that drive cell cycle progression, Cyclin C has dual roles: it participates in transcriptional regulation and, under stress conditions, promotes apoptosis by relocating to mitochondria to initiate mitochondrial fission.

The Ab-275 epitope corresponds to a region surrounding amino acid residue 275 in human Cyclin C. This antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study Cyclin C expression, localization, and interactions in various cellular contexts. Researchers employ it to explore Cyclin C’s roles in cancer (where its dysregulation may influence tumor growth or suppression), neurodegenerative diseases, and metabolic disorders. Its specificity and reliability make it valuable for elucidating mechanisms of transcriptional regulation linked to cell cycle checkpoints, stress adaptation, and mitochondrial dynamics.

Cyclin C (Ab-275) antibody thus serves as a critical reagent for dissecting pathways that balance cell survival, death, and homeostasis in health and disease.

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