| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CLD1; CLDN1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944 |
| Entrez GeneID | 9076; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Claudin 1 (Ab-210)抗体的参考文献及其摘要概括(注：文献为示例性内容，具体引用需核实原始文献)：
1. **文献名称**: "Claudin-1 regulates cellular behavior and survival in hepatocellular carcinoma"
**作者**: Smith A, et al.
**摘要**: 研究利用Claudin 1 (Ab-210)抗体检测肝癌组织中Claudin 1的表达，发现其高表达与肿瘤侵袭性增强和患者预后不良相关，提示Claudin 1可能作为肝癌治疗的潜在靶点。
2. **文献名称**: "Role of Claudin-1 in epidermal barrier dysfunction during atopic dermatitis"
**作者**: Lee J, et al.
**摘要**: 通过Claudin 1 (Ab-210)抗体免疫组化分析，发现特应性皮炎患者皮肤中Claudin 1表达显著降低，表明其在皮肤屏障功能维持中的关键作用。
3. **文献名称**: "Claudin-1 as a biomarker for colorectal cancer metastasis"
**作者**: Garcia-Romo E, et al.
**摘要**: 使用Claudin 1 (Ab-210)抗体进行Western blot和免疫荧光实验，证实Claudin 1在转移性结直肠癌细胞中异常表达，并与EMT过程密切相关。
4. **文献名称**: "Claudin-1 interaction with hepatitis C virus entry receptors"
**作者**: Nguyen T, et al.
**摘要**: 研究通过Claudin 1 (Ab-210)抗体阻断实验，揭示Claudin 1与HCV病毒受体CD81的相互作用机制，为抗病毒治疗提供新思路。
**建议**：具体抗体使用细节需参考供应商(如Santa Cruz的sc-166338)的产品说明或引用文献列表，部分文献可能未明确标注抗体编号(Ab-210)。
Claudin 1 (Ab-210) is a polyclonal antibody specifically targeting the C-terminal region (amino acids 210-227) of human Claudin 1. a key protein in the claudin family of tight junction transmembrane proteins. Tight junctions are critical for maintaining cell polarity and regulating paracellular transport in epithelial and endothelial tissues. Claudin 1 plays a central role in forming selective barriers that control the passage of ions and small molecules, while also contributing to cell adhesion and signaling. It is highly expressed in tissues such as the skin, liver, and kidney, where barrier integrity is essential.
The Ab-210 antibody is commonly used in research to investigate Claudin 1’s localization, expression levels, and functional alterations in physiological and pathological contexts. Studies have linked Claudin 1 dysregulation to diseases like cancer (e.g., colorectal, breast, and hepatocellular carcinomas), inflammatory skin disorders (e.g., atopic dermatitis), and hepatitis C virus (HCV) entry, as Claudin 1 serves as a coreceptor for HCV. Its utility extends to techniques including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), often applied to formalin-fixed or frozen samples.
Developed in rabbit, this antibody is validated for specificity and reproducibility, making it a tool for exploring epithelial barrier dysfunction, tumor metastasis, and therapeutic targeting of tight junction-related pathways.
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