| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TRKB; trk-B; GP145-TrkB |
| Entrez GeneID | 4915; |
| WB Predicted band size | 145kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.703~707 (T-D-Y -Y-R) derived from Human TrkB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TrkB (Ab-705)抗体的3篇参考文献(注：因具体文献检索受限，以下内容基于模拟生成，建议通过学术数据库验证)：
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1. **文献名称**：*Phosphorylation of TrkB at Tyr705 regulates synaptic plasticity and spatial memory formation*
**作者**：Smith A, et al.
**摘要**：该研究通过TrkB (Ab-705)抗体检测海马神经元中TrkB受体在Tyr705位点的磷酸化水平，发现该位点的磷酸化对BDNF诱导的突触可塑性和空间记忆形成至关重要。
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2. **文献名称**：*TrkB activation and downstream signaling in neuroprotection against oxidative stress*
**作者**：Chen L, et al.
**摘要**：利用TrkB (Ab-705)抗体证实，神经元在氧化应激条件下，TrkB的Y705磷酸化通过激活PI3K/Akt通路发挥神经保护作用，为神经退行性疾病治疗提供新靶点。
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3. **文献名称**：*Differential roles of TrkB phosphorylation sites in mediating neuronal survival and differentiation*
**作者**：Kimura H, et al.
**摘要**：通过对比TrkB不同磷酸化位点(包括Y705)的功能，研究发现Y705磷酸化主要参与神经元存活而非分化，相关实验依赖于特异性抗体TrkB (Ab-705)的Western blot分析。
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**提示**：若需具体文献，建议在PubMed或Google Scholar中搜索关键词“TrkB Y705 phosphorylation antibody”或联系抗体供应商(如CST、Abcam)获取引用文献列表。
The TrkB (Ab-705) antibody is a specialized tool used to study the tropomyosin receptor kinase B (TrkB), a key receptor tyrosine kinase encoded by the *NTRK2* gene. TrkB binds brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), playing critical roles in neuronal survival, synaptic plasticity, and cognitive functions. Dysregulation of TrkB signaling is implicated in neurodegenerative diseases, mood disorders, and cancer. The "Ab-705" designation typically refers to an antibody targeting a specific phosphorylated tyrosine residue (e.g., Tyr705) within TrkB’s activation loop. Phosphorylation at this site is essential for TrkB’s kinase activity and downstream signaling via pathways like MAPK/ERK, PI3K/Akt, and PLCγ.
This antibody is widely used in techniques such as Western blotting, immunohistochemistry, or immunoprecipitation to detect TrkB activation states in research models. It helps investigate mechanisms underlying neuroprotection, synaptic adaptation, or oncogenic TrkB signaling in cancers like neuroblastoma or glioblastoma. Researchers also utilize it to evaluate therapeutic interventions targeting TrkB, including small-molecule inhibitors or BDNF-mimetics. By enabling precise detection of activated TrkB, Ab-705 contributes to understanding its dual role in health and disease, bridging basic neuroscience with translational applications.
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