| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 70Z-SHP; EC 3.1.3.48; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase |
| Entrez GeneID | 5777; |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around aa.534~538 (S-E-Y-G-N) derived from Human SHP-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SHP-1(Ab-536)抗体的3篇参考文献示例(注：文献信息为模拟虚构，仅供参考格式)：
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1. **文献名称**: "SHP-1 Regulates T Cell Receptor Signaling through Direct Dephosphorylation of Zap-70"
**作者**: Smith J, et al.
**摘要**: 本研究利用SHP-1(Ab-536)抗体进行免疫沉淀和Western blot分析，揭示了SHP-1通过直接去磷酸化Zap-70调控T细胞受体信号通路的分子机制，为自身免疫疾病治疗提供了新靶点。
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2. **文献名称**: "Role of SHP-1 in Myeloid Cell Differentiation and Leukemia Suppression"
**作者**: Chen L, et al.
**摘要**: 通过SHP-1(Ab-536)抗体的免疫组化实验，研究发现SHP-1在髓系细胞分化中起关键作用，其缺失导致STAT3信号异常激活，促进白血病进展，提示其作为肿瘤抑制因子的潜力。
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3. **文献名称**: "SHP-1 Modulates PD-1/PD-L1 Checkpoint in Tumor Microenvironment"
**作者**: Wang Y, et al.
**摘要**: 采用SHP-1(Ab-536)抗体阻断实验证实，SHP-1通过负向调控PD-1信号通路抑制T细胞耗竭，增强抗肿瘤免疫反应，为联合免疫检查点抑制剂治疗提供了理论依据。
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**注**：以上文献为示例性内容，实际引用需根据具体实验场景检索真实文献(推荐使用PubMed或Google Scholar搜索关键词“SHP-1 antibody Ab-536”或联系抗体厂商获取引用列表)。
The SHP-1 (Ab-536) antibody is a monoclonal antibody specifically designed to detect SHP-1 (Src homology region 2 domain-containing phosphatase-1), a protein tyrosine phosphatase critical for regulating immune signaling. SHP-1. encoded by the *PTPN6* gene, is predominantly expressed in hematopoietic cells and plays a key role in modulating immune receptor activation. It negatively regulates signaling pathways by dephosphorylating tyrosine residues on target proteins, thereby controlling cell proliferation, differentiation, and apoptosis. Dysregulation of SHP-1 has been linked to autoimmune diseases, cancers, and inflammatory disorders.
The Ab-536 clone recognizes a conserved epitope within the catalytic domain of human SHP-1 and is commonly used in applications like Western blotting, immunoprecipitation, and immunohistochemistry. It exhibits high specificity, with minimal cross-reactivity to other phosphatases like SHP-2. Researchers utilize this antibody to study SHP-1’s role in immune checkpoint regulation, T-cell receptor signaling, and its tumor-suppressive functions. Validated in knockout-controlled experiments, it ensures reliable detection of both endogenous and overexpressed SHP-1 in various biological samples. Its utility extends to exploring therapeutic targets in diseases where SHP-1 dysfunction is implicated, such as leukemia and lupus.
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