Rabbit Polyclonal HSP27(Ab-82) Antibody

HSP27 (Ab-82) antibody targets the human heat shock protein 27 (HSP27), also known as HSPB1. a member of the small heat shock protein (sHSP) family. HSP27 is a 27 kDa chaperone protein that plays a critical role in cellular stress responses, including thermotolerance, oxidative stress resistance, and apoptosis regulation. It stabilizes cytoskeletal structures, modulates protein folding, and interacts with key signaling pathways, such as the p38 MAPK pathway. The "Ab-82" designation typically refers to an antibody specific to a phosphorylated form of HSP27. often at serine 82 (Ser82), a key post-translational modification site. Phosphorylation at Ser82 regulates HSP27’s oligomerization, chaperone activity, and its ability to interact with client proteins or cellular components. Dysregulation of HSP27 expression or phosphorylation is implicated in cancer progression, neurodegenerative diseases, and inflammatory conditions. The HSP27 (Ab-82) antibody is widely used in research to study stress response mechanisms, disease biomarkers, and therapeutic targets. It is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, providing insights into HSP27’s spatial expression and activation status under physiological or pathological conditions.