Rabbit Polyclonal BRCA1(Ab-1423) Antibody

The BRCA1 (Ab-1423) antibody is a widely used reagent in cancer research, specifically targeting the BRCA1 protein, a critical tumor suppressor involved in DNA repair and genomic stability. BRCA1 (BReast CAncer gene 1) encodes a large nuclear protein that plays a central role in homologous recombination repair of double-strand DNA breaks, cell cycle checkpoint control, and transcriptional regulation. Mutations in BRCA1 are strongly linked to hereditary breast and ovarian cancers. The Ab-1423 antibody, often generated in rabbits, recognizes an epitope within the N-terminal region (amino acids 1-304) of human BRCA1. It is commonly employed in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to study BRCA1 expression, localization, and function in cell lines, tissues, or tumor samples. Researchers use this antibody to explore BRCA1’s role in DNA damage response pathways, its interaction with partner proteins (e.g., BARD1. RAD51), and its relevance in cancer progression or therapy resistance. Validated in knockdown/knockout models, Ab-1423 helps assess BRCA1 status in clinical samples, aiding in mechanistic studies or biomarker analysis. Its specificity and reliability make it a key tool for investigating BRCA1-related molecular mechanisms and therapeutic vulnerabilities in BRCA1-deficient cancers.