Rabbit Polyclonal IRS-1(Ab-636) Antibody

The IRS-1 (Ab-636) antibody is a widely used tool in biomedical research to study the insulin receptor substrate 1 (IRS-1) protein, a critical mediator of insulin and insulin-like growth factor (IGF) signaling pathways. IRS-1 acts as a docking protein that transmits signals from activated insulin/IGF-1 receptors to downstream effectors, regulating metabolic processes, cell growth, and survival. Dysregulation of IRS-1 is implicated in insulin resistance, type 2 diabetes, and certain cancers. The Ab-636 antibody, typically generated in rabbits or mice, targets specific epitopes of human, mouse, or rat IRS-1. enabling its detection in applications like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Researchers rely on this antibody to investigate IRS-1 expression levels, post-translational modifications (e.g., phosphorylation at key tyrosine or serine residues), and interactions with signaling molecules. Its specificity is often validated through knockout controls or siRNA-mediated knockdown experiments. Studies using IRS-1 (Ab-636) have contributed to understanding molecular mechanisms in metabolic disorders, cancer biology, and therapeutic responses. Proper validation in specific experimental systems is recommended due to potential cross-reactivity or variability across sample types.