Rabbit Polyclonal CDC2(Ab-15) Antibody

CDC2 (Ab-15) is a monoclonal antibody specifically designed to target the CDC2 protein, also known as cyclin-dependent kinase 1 (CDK1), a critical regulator of cell cycle progression. CDC2 plays a pivotal role in driving the transition from the G2 phase to the M phase by forming complexes with cyclin B, enabling phosphorylation of substrates necessary for mitotic entry. Dysregulation of CDC2 is associated with uncontrolled cell proliferation and cancer, making it a key focus in oncology and cell biology research. The Ab-15 clone recognizes a conserved epitope within the N-terminal region of human CDC2. enabling its detection across multiple species, including mouse and rat. It is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CDC2 expression, localization, and activity in various cellular contexts. Developed in murine hosts, this antibody has been validated for specificity and reliability in both normal and cancer-derived cell lines. Its applications extend to investigating cell cycle checkpoints, DNA damage responses, and therapeutic interventions targeting mitotic regulation. Researchers frequently employ CDC2 (Ab-15) to explore mechanisms underlying tumorigenesis, chemotherapy resistance, and developmental biology processes linked to cell division control.