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Rabbit Polyclonal TFB2M Antibody

  • 中文名: TFB2M抗体
  • 别    名: Dimethyladenosine transferase 2, mitochondrial, 211-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-ade
货号: IPDX34802
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDimethyladenosine transferase 2, mitochondrial, 211-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, TFB2M, NS5ATP5
Entrez GeneID64216
WB Predicted band size45.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TFB2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human TFB2M.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TFB2M抗体的3篇参考文献概览:

1. **文献名称**:*"The role of TFB2M in mitochondrial transcription and its association with colorectal cancer"*

**作者**:Smith J, et al.

**摘要**:该研究利用特异性TFB2M抗体探究其在结直肠癌中的表达水平,发现TFB2M通过调控线粒体DNA转录影响肿瘤代谢,抗体通过Western blot和免疫组化验证其高特异性。

2. **文献名称**:*"Characterization of mitochondrial transcription factor B2 (TFB2M) antibodies in metabolic disorders"*

**作者**:Lee H, et al.

**摘要**:研究开发了针对TFB2M的多克隆抗体,用于检测其在糖尿病模型中的表达变化,证实TFB2M异常表达与线粒体功能紊乱相关,抗体应用于免疫荧光定位线粒体内蛋白。

3. **文献名称**:*"TFB2M mutations and mitochondrial encephalopathy: Antibody-based diagnostic approaches"*

**作者**:Garcia R, et al.

**摘要**:通过TFB2M抗体分析患者肌肉活检样本,揭示特定突变导致蛋白稳定性下降,提出抗体可作为诊断线粒体脑肌病的生物标志物工具。

注:以上文献名为示例性概括,实际引用需根据具体论文调整。建议通过PubMed或Google Scholar以“TFB2M antibody”或“mitochondrial transcription factor B2 antibody”为关键词检索最新研究。

背景信息

The TFB2M antibody targets the Transcription Factor B2. Mitochondrial (TFB2M), a nuclear-encoded protein critical for mitochondrial gene expression. TFB2M plays a key role in mitochondrial transcription by interacting with mitochondrial RNA polymerase (POLRMT) and transcription factor A (TFAM) to facilitate the initiation of mitochondrial DNA (mtDNA) transcription. It is structurally related to bacterial rRNA methyltransferases and is implicated in the methylation of 12S rRNA, a modification essential for proper mitochondrial ribosome assembly and function. Dysregulation of TFB2M has been linked to mitochondrial disorders, metabolic diseases, and cancer, particularly acute myeloid leukemia (AML), where its overexpression correlates with altered energy metabolism and disease progression. The TFB2M antibody is widely used in research to study mitochondrial biogenesis, oxidative phosphorylation, and cellular energy homeostasis. Applications include Western blotting, immunofluorescence, and immunohistochemistry to assess TFB2M expression levels, subcellular localization, and interactions with other mitochondrial proteins. Its role in bridging nuclear signaling with mitochondrial function makes it a valuable tool for exploring diseases associated with mitochondrial dysfunction and metabolic reprogramming.

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