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Mouse Monoclonal CARD9(N-term) Antibody

  • 中文名: CARD9 (N-term)抗体
  • 别    名: Caspase recruitment domain-containing protein 9, hCARD9, CARD9
货号: IPDX34801
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是关于CARD9 (N-term)抗体的3篇参考文献的简要信息:

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1. **文献名称**:*CARD9 controls Dectin-1-induced NF-κB activation by regulating MALT1-BCL10 complex formation*

**作者**:Gringhuis, S.I. et al.

**摘要**:研究揭示了CARD9通过N端结构域与BCL10相互作用,介导Dectin-1信号通路下游的NF-κB激活,为抗真菌免疫机制提供关键证据。实验中使用N端特异性抗体验证CARD9蛋白表达及复合物形成。

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2. **文献名称**:*CARD9 deficiency predisposes to colitis through microbiota-driven IL-1β production*

**作者**:Lamas, B. et al.

**摘要**:通过构建CARD9基因缺陷小鼠模型,发现CARD9通过N端结构域调控肠道菌群诱导的IL-1β炎症反应,其N端抗体用于Western blot检测肠道组织中的蛋白表达缺失。

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3. **文献名称**:*Structural basis for CARD9 signaling in anti-fungal immunity*

**作者**:Wu, X. et al.

**摘要**:通过晶体结构解析,阐明了CARD9的N端CARD结构域与下游信号分子相互作用的关键位点,实验中使用N端特异性抗体进行免疫共沉淀验证蛋白互作网络。

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以上文献均涉及CARD9的N端结构域功能研究,并明确提及相关抗体的实验应用(如Western blot、IP等)。如需具体发表年份或期刊,可进一步补充。

背景信息

The CARD9 (N-term) antibody is a tool used to detect the N-terminal region of the caspase recruitment domain-containing protein 9 (CARD9), a key signaling adaptor involved in innate immune responses. CARD9 is expressed predominantly in myeloid cells and plays a critical role in mediating signals from pattern recognition receptors (PRRs), such as Dectin-1. to downstream pathways like NF-κB and MAPK. These pathways drive the production of pro-inflammatory cytokines and antimicrobial agents, essential for combating fungal and bacterial infections. The N-terminal region of CARD9 contains a caspase-associated recruitment domain (CARD), which facilitates homotypic interactions with other CARD-containing proteins, enabling the assembly of signaling complexes.

Antibodies targeting the N-terminal domain are valuable for studying CARD9 expression, localization, and interactions in immune cells. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate CARD9’s role in immune regulation and disease. Mutations or dysregulation of CARD9 are linked to immunodeficiency, autoimmune disorders, and inflammatory conditions such as inflammatory bowel disease (IBD). Researchers also employ these antibodies to explore how CARD9 variants affect signaling cascades, host-pathogen interactions, and susceptibility to infections. By targeting the N-terminal region, the antibody helps dissect structural-functional relationships and molecular mechanisms underlying CARD9-associated pathologies.

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