| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Disco-interacting protein 2 homolog A, DIP2 homolog A, DIP2A, C21orf106, DIP2, KIAA0184 |
| Entrez GeneID | 23181 |
| WB Predicted band size | 170.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DIP2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 934-969 amino acids from the Central region of human DIP2A. |
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以下是关于DIP2A抗体的模拟参考文献示例(实际文献可能需要通过学术数据库验证)：
1. **文献名称**：*DIP2A regulates synaptic plasticity and cognitive function through epigenetic mechanisms*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性DIP2A抗体进行免疫组化及Western blot分析，揭示DIP2A在小鼠海马神经元中的突触定位，并发现其通过调控组蛋白修饰影响认知功能。
2. **文献名称**：*Development of a novel polyclonal antibody for DIP2A and its application in glioma progression*
**作者**：Chen L, et al.
**摘要**：作者开发了一种兔源多克隆DIP2A抗体，验证其特异性后应用于胶质瘤组织，发现DIP2A表达与肿瘤恶性程度呈负相关，提示其潜在抑癌作用。
3. **文献名称**：*DIP2A mutations in autism spectrum disorder disrupt protein stability and dendritic spine formation*
**作者**：Wang Y, et al.
**摘要**：通过商业DIP2A抗体检测患者源性神经元，发现ASD相关突变导致DIP2A蛋白降解加速，并损害树突棘发育，为病理机制提供新证据。
4. **文献名称**：*DIP2A antibody-based proteomic analysis reveals its interaction with mitochondrial proteins in Parkinson's models*
**作者**：Kumar R, et al.
**摘要**：利用DIP2A抗体进行免疫共沉淀-质谱分析，发现DIP2A与线粒体复合体蛋白相互作用，其表达下降可能导致帕金森模型中的神经元能量代谢障碍。
(注：以上为模拟文献，实际引用需查询PubMed、Google Scholar等平台。)
**Background of DIP2A Antibody**
DIP2A (Disco-interacting protein 2 homolog A) is an evolutionarily conserved protein implicated in transcriptional regulation, epigenetic modulation, and neural development. It shares structural homology with the *Drosophila* DIP2 protein, which regulates axon guidance and synaptic plasticity. In mammals, DIP2A is highly expressed in the brain and interacts with chromatin-modifying complexes, suggesting a role in neurodevelopment. Studies link *DIP2A* gene variants to neuropsychiatric disorders, including autism spectrum disorder (ASD) and intellectual disability, as well as neurodegenerative conditions like Alzheimer’s disease.
DIP2A antibodies are essential tools for investigating its expression, localization, and function. These antibodies, often developed against specific epitopes (e.g., N-terminal or C-terminal regions), enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research using DIP2A antibodies has revealed its nuclear localization and association with DNA methylation machinery, supporting its involvement in epigenetic regulation.
Additionally, DIP2A is studied in cancer biology, where aberrant expression correlates with tumor progression. For example, DIP2A downregulation in glioblastoma or lung cancer may influence oncogenic pathways. Validated antibodies help dissect these mechanisms, aiding therapeutic exploration.
Overall, DIP2A antibodies are pivotal for unraveling the protein’s roles in health and disease, bridging molecular insights to potential clinical applications.
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