| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 4F17, Olfactory receptor 4F11, Olfactory receptor 4F18, Olfactory receptor 4F19, OR4F17, OR4F11P, OR4F18, OR4F19 |
| Entrez GeneID | 81099 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR4F17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the N-terminal region of human OR4F17. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于OR4F17(N端)抗体的研究文献相对有限，以下为示例性参考文献(注：实际文献可能需要进一步检索验证)：
1. **"Characterization of olfactory receptor OR4F17 expression in human tissues using a novel N-terminal specific antibody"**
- 作者：Smith A, et al.
- 摘要：本研究开发了一种针对OR4F17蛋白N端表位的多克隆抗体，通过Western blot和免疫组化验证其特异性，发现OR4F17在嗅觉上皮和睾丸组织中低水平表达，提示其潜在的非嗅觉功能。
2. **"Proteomic analysis of olfactory receptor family highlights OR4F17 as a potential biomarker in glioblastoma"**
- 作者：Lee J, et al.
- 摘要：利用OR4F17(N-term)抗体对胶质母细胞瘤组织进行蛋白质组学分析，发现OR4F17异常高表达与肿瘤进展相关，可能成为诊断标志物。
3. **"Antibody validation for olfactory receptors: A case study of OR4F17 in neurodegenerative diseases"**
- 作者：Garcia R, et al.
- 摘要：系统性验证了OR4F17抗体的特异性，发现其在阿尔茨海默病患者脑脊液中的表达变化，提示其可能与神经退行性过程相关。
4. **"OR4F17 interacts with G-protein signaling pathways in cancer cell lines"**
- 作者：Chen H, et al.
- 摘要：通过免疫共沉淀(使用N端抗体)发现OR4F17与G蛋白偶联受体信号通路存在相互作用，可能影响癌细胞迁移。
**建议**：上述文献为示例，实际研究中建议通过PubMed或抗体供应商(如Sigma-Aldrich、Abcam)的产品引用列表检索具体文献，或使用关键词“OR4F17 antibody”、“OR4F17 N-terminal”结合相关研究领域进一步筛选。
The OR4F17 (N-term) antibody is a specialized immunological tool designed to target the N-terminal region of the olfactory receptor family 4 subfamily F member 17 (OR4F17), a protein encoded by the OR4F17 gene in humans. As part of the olfactory receptor (OR) superfamily, OR4F17 belongs to G protein-coupled receptors (GPCRs) that mediate odorant detection in the olfactory epithelium. While ORs are primarily associated with smell perception, some, including OR4F17. exhibit ectopic expression in non-olfactory tissues, suggesting potential roles in cellular signaling, tissue development, or disease pathways, though its precise biological functions remain under investigation.
This antibody is typically generated in host species (e.g., rabbit or mouse) using synthetic peptides or recombinant proteins corresponding to the N-terminal domain of OR4F17. It is widely utilized in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect OR4F17 expression levels, localization, and tissue distribution. Validation often includes knockout controls or siRNA silencing to confirm specificity. Commercial suppliers may provide additional data on cross-reactivity and batch consistency.
Studies involving OR4F17 (N-term) antibodies have explored its potential relevance in cancer, neurological disorders, or metabolic conditions, leveraging its role in cellular communication. However, the functional significance of OR4F17 in these contexts remains unclear, necessitating further mechanistic studies. Researchers value this antibody for probing OR4F17's enigmatic roles beyond olfaction, aiding in the broader understanding of orphan GPCRs in human physiology and pathology.
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