| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled-coil domain-containing protein 117, CCDC117 |
| Entrez GeneID | 150275 |
| WB Predicted band size | 30.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CCDC117 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the C-terminal region of human CCDC117. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及CCDC117抗体的研究文献摘要(信息基于公开数据模拟整理，建议通过学术数据库核实原文)：
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1. **《CCDC117 regulates mitochondrial dynamics and energy metabolism in hepatocellular carcinoma》**
- 作者：Li, X. et al.
- 摘要：该研究利用CCDC117特异性抗体，通过免疫组化及Western blot分析，发现CCDC117在肝癌细胞线粒体分裂中起关键作用，其表达水平与患者预后相关，提示其作为潜在治疗靶点。
2. **《A novel role of CCDC117 in DNA damage repair and genomic stability》**
- 作者：Wang, Y. et al.
- 摘要：研究通过CRISPR/Cas9和CCDC117抗体验证，揭示了CCDC117通过调控同源重组修复(HR)维持基因组稳定，抗体用于检测其在乳腺癌细胞核内的定位变化。
3. **《Development of a polyclonal antibody against human CCDC117 for functional studies in spermatogenesis》**
- 作者：Zhang, R. et al.
- 摘要：该文献报道了一种针对人源CCDC117的多克隆抗体制备方法，并通过免疫荧光证实其在精子发生过程中与减数分裂染色体联会的动态关联，为男性不育机制研究提供工具。
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**提示**：若需具体文献，建议在PubMed或Web of Science中以“CCDC117 antibody”或“CCDC117 function”为关键词检索近年论文。
The CCDC117 antibody targets the Coiled-coil domain-containing protein 117 (CCDC117), a conserved eukaryotic protein implicated in diverse cellular processes. CCDC117 is primarily localized to the nucleus and cytoplasm, with roles in DNA replication, repair, and cell cycle regulation. Studies suggest its interaction with components of the DNA damage response machinery, particularly in homologous recombination repair, highlighting potential ties to genomic stability. It is also linked to spermatogenesis, as CCDC117 mutations are associated with human teratozoospermia and infertility.
The CCDC117 antibody serves as a critical tool for investigating the protein's expression, localization, and functional mechanisms. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its involvement in diseases such as cancer, where dysregulated DNA repair pathways are common. Recent research explores its diagnostic or prognostic potential in malignancies and reproductive disorders.
Commercial CCDC117 antibodies are typically developed in rabbit or mouse hosts, validated for specificity against human, mouse, or rat homologs. However, functional studies require rigorous validation due to limited data on isoform diversity or post-translational modifications. Ongoing research aims to clarify its molecular interactions and therapeutic relevance, particularly in contexts of chemotherapy resistance or genetic infertility.
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