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Rabbit Polyclonal PIAS2(PIASx1) Antibody

  • 中文名: PIAS2 (PIASx1)抗体
  • 别    名: E3 SUMO-protein ligase PIAS2, 632-, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, Msx-interacting zinc finger protein, Miz1, PIAS-NY protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2, PIA
货号: IPDX34251
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesE3 SUMO-protein ligase PIAS2, 632-, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, Msx-interacting zinc finger protein, Miz1, PIAS-NY protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2, PIAS2, PIASX
Entrez GeneID9063
WB Predicted band size68.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PIAS2 (PIASx1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human PIAS2 (PIASx1).
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于PIAS2(PIASx1)抗体的3篇参考文献示例(内容为模拟概括,仅供参考):

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1. **文献名称**:*PIAS2 regulates STAT3-mediated signaling in colorectal cancer cells*

**作者**:Smith A, et al.

**摘要**:本研究利用PIAS2特异性抗体通过Western blot和免疫沉淀技术,发现PIAS2通过抑制STAT3的SUMO化修饰调控结直肠癌细胞增殖和迁移,揭示了其在肿瘤进展中的作用机制。

2. **文献名称**:*PIASx1 modulates androgen receptor activity in prostate cancer*

**作者**:Lee C, et al.

**摘要**:通过免疫荧光和ChIP实验结合PIASx1抗体,研究证明PIAS2(PIASx1)与雄激素受体(AR)相互作用,影响AR靶基因的转录活性,为前列腺癌治疗提供潜在靶点。

3. **文献名称**:*Role of PIAS2 in neuronal differentiation and SUMOylation pathways*

**作者**:Garcia R, et al.

**摘要**:本研究使用PIAS2抗体进行免疫组化分析,发现PIAS2在小鼠脑组织中高表达,并通过调节SUMO化通路促进神经干细胞分化,提示其在神经系统发育中的关键功能。

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注:以上文献信息为示例,实际引用时需根据具体研究内容检索PubMed、Google Scholar等平台获取真实文献。

背景信息

The PIAS2 (Protein Inhibitor of Activated STAT 2), also known as PIASx1. is a member of the PIAS family of E3 SUMO ligases that regulate post-translational protein modification, particularly SUMOylation. This antibody targets the PIAS2 protein, which plays a critical role in modulating transcriptional activity by interacting with transcription factors (e.g., STATs, NF-κB, p53) and chromatin-remodeling complexes. PIAS2 is involved in diverse cellular processes, including inflammation, apoptosis, DNA repair, and hormone signaling. Researchers use PIAS2 antibodies primarily in Western blotting, immunoprecipitation, and immunofluorescence to study its expression, localization, and molecular interactions. Dysregulation of PIAS2 has been implicated in cancer, immune disorders, and neurodegenerative diseases, making it a focus in therapeutic research. The antibody's specificity is validated using knockout controls or siRNA-mediated depletion to ensure accurate detection of PIAS2 isoforms (α and β). Commercial PIAS2 antibodies are typically raised in rabbits or mice, with monoclonal and polyoclonal options available. Its application spans cancer biology, immunology, and studies of SUMOylation-dependent signaling pathways.

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