| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 52H1, Olfactory receptor OR11-45, OR52H1 |
| Entrez GeneID | 390067 |
| WB Predicted band size | 35.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR52H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the C-terminal region of human OR52H1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR52H1抗体的参考文献示例(注：部分信息为模拟生成，实际文献可能需要进一步核实)：
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1. **文献名称**: *Characterization of an OR52H1-specific antibody for olfactory receptor studies*
**作者**: Müller A, et al.
**摘要**: 本研究开发了一种针对OR52H1的多克隆抗体，通过免疫印迹和免疫组化验证其特异性，证实OR52H1在人类嗅觉上皮和非嗅觉组织(如前列腺)中的差异表达，为研究其生理功能提供工具。
2. **文献名称**: *OR52H1 expression in prostate cancer: A potential diagnostic marker*
**作者**: Smith R, et al.
**摘要**: 利用抗OR52H1抗体检测前列腺癌组织样本，发现OR52H1在癌细胞中显著高表达，提示其可能作为癌症生物标志物，并参与肿瘤微环境信号调控。
3. **文献名称**: *Antibody-based localization of olfactory receptors in human skin*
**作者**: Flegel C, et al.
**摘要**: 通过定制OR52H1抗体，揭示其在皮肤角质形成细胞中的膜定位，表明OR52H1可能参与化学感应或皮肤屏障功能，拓展了嗅觉受体在非嗅觉系统中的角色认知。
4. **文献名称**: *Cross-reactivity validation of anti-OR52H1 antibody in murine models*
**作者**: Zhang Y, et al.
**摘要**: 评估OR52H1抗体在小鼠组织中的交叉反应性，发现其特异性结合人源受体，但与非人灵长类存在部分交叉反应，为跨物种研究提供实验依据。
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**备注**：以上文献信息为示例性模拟，实际研究中OR52H1抗体的直接报道可能较少。建议通过数据库(如PubMed、Google Scholar)结合关键词“OR52H1 antibody”或“OR52H1 immunohistochemistry”检索最新文献，或参考涉及OR52H1功能研究的论文中提及的抗体使用方法。
The OR52H1 antibody is a research tool designed to target the olfactory receptor 52H1 (OR52H1), a member of the olfactory receptor (OR) family, which constitutes the largest group of G protein-coupled receptors (GPCRs). ORs are primarily expressed in olfactory sensory neurons, where they detect odorant molecules and initiate signal transduction. OR52H1 is localized on chromosome 11 in humans and is thought to recognize specific odorants, though its exact ligands and physiological roles remain under investigation. Beyond olfaction, some ORs, including OR52H1. have been detected in non-olfactory tissues (e.g., brain, liver, and testes), suggesting potential roles in cellular signaling or disease pathways.
The OR52H1 antibody is typically developed for applications such as Western blotting, immunohistochemistry, or immunofluorescence to study the receptor’s expression, localization, and function. These antibodies are often raised in host species like rabbits or mice, targeting specific epitopes within the receptor’s extracellular or intracellular domains. Validation steps, including knockout controls, are critical to confirm specificity due to the high sequence homology among OR family members.
Research involving the OR52H1 antibody contributes to understanding OR biology, sensory signaling mechanisms, and potential therapeutic targets in diseases where ORs may be dysregulated, such as cancer or metabolic disorders. However, challenges persist in characterizing OR52H1’s precise roles, partly due to limited antibody availability and the complexity of OR functional studies in heterologous systems.
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