Cat: PA1000-9740

Recombinant Human CAV1 Protein,His

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关键信息

  • 基因名

    CAV1

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CAV1;CAV;Caveolin-1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q03135

  • 表达区间

    1-178aa

  • 氨基酸序列

    MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEID LVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFY RLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSI YVHTVCDPLFEAVGKIFSNVRINLQKEI

  • 分子量

    46 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

Caveolin-1 (CAV1) is a principal structural protein of caveolae, small invaginations in the plasma membrane of many cell types, which play a crucial role in various cellular processes, including signal transduction, lipid metabolism, and endocytosis. Research over the years has highlighted CAV1's important functions in regulating cellular signaling pathways, particularly those related to cancer development, cardiovascular diseases, and metabolic disorders. Its role as a tumor suppressor in several contexts suggests that alterations in CAV1 expression or function can lead to tumorigenesis. In addition, CAV1 is implicated in the modulation of several key signaling molecules, such as Ras and eNOS, thereby influencing cell proliferation and vascular function. The production of recombinant CAV1 protein has become a focus of study, as it provides a powerful tool for investigating the molecular mechanisms underlying its functions. By using recombinant techniques, researchers can produce CAV1 in a controlled environment, allowing for detailed studies on its structure-function relationships, interactions with other proteins, and its effects on cellular behavior. Such studies are vital for developing therapeutic strategies aimed at targeting CAV1-related pathways in diseases, particularly cancer. Consequently, the exploration of CAV1 as a recombinant protein not only enhances our understanding of fundamental biological processes but also opens up potential avenues for clinical applications.

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