Mouse Monoclonal TIMP2 Antibody

TIMP2 (Tissue Inhibitor of Metalloproteinases 2) is a key regulatory protein involved in extracellular matrix (ECM) homeostasis by inhibiting matrix metalloproteinases (MMPs), particularly MMP2 and MMP9. It plays dual roles in tissue remodeling, angiogenesis, and cancer progression, balancing ECM degradation and cellular processes. TIMP2 antibodies are essential tools for detecting and quantifying TIMP2 expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study TIMP2's involvement in pathological conditions, including fibrosis, neurodegenerative diseases, and tumor metastasis. In cancer, TIMP2’s role is context-dependent, acting as both a tumor suppressor (by inhibiting MMP-mediated invasion) and a promoter (via MMP-independent signaling pathways). Antibodies targeting specific TIMP2 epitopes help elucidate its interactions with MMPs, cell surface receptors (e.g., integrins), and growth factors. Recent studies also explore TIMP2's potential as a biomarker for diseases like Alzheimer’s and chronic kidney disease. Commercial TIMP2 antibodies are typically validated for specificity against human, mouse, or rat isoforms, often distinguishing between free TIMP2 and its complexes with MMPs. Ongoing research aims to harness TIMP2-targeting therapies, underscoring the antibody's importance in translational medicine.