| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | U6 snRNA-associated Sm-like protein LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5, LSM2, C6orf28, G7B |
| Entrez GeneID | 57819 |
| WB Predicted band size | 10.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LSM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-89 amino acids from human LSM2. |
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以下是关于LSM2抗体的3篇参考文献摘要示例：
1. **文献名称**：*LSM2-8 complex promotes spliceosomal U6 snRNA remodeling and ensures faithful pre-mRNA splicing*
**作者**：Schümperli, D. et al.
**摘要**：本研究揭示了LSM2-8蛋白复合体在剪接体动态组装中的作用，通过免疫共沉淀(使用LSM2抗体)和RNA干扰技术，发现LSM2缺失导致U6 snRNA稳定性下降，影响pre-mRNA剪接的准确性。
2. **文献名称**：*LSM2 as a potential oncogene in glioblastoma progression*
**作者**：He, X. et al.
**摘要**：该研究利用LSM2特异性抗体进行免疫组化(IHC)和Western blot分析，发现胶质母细胞瘤组织中LSM2表达显著上调，其高表达与患者预后不良相关，机制涉及调控细胞周期蛋白依赖性激酶(CDK)通路。
3. **文献名称**：*The role of LSM2 in maintaining RNA homeostasis under oxidative stress*
**作者**：Huang, L. et al.
**摘要**：通过LSM2抗体进行染色质免疫沉淀(ChIP)和荧光定位实验，证明LSM2在氧化应激条件下保护细胞RNA免受降解，并参与应激颗粒(stress granule)的形成，维持RNA稳定性。
(注：以上文献为示例性内容，实际引用时需根据具体研究补充真实文献信息。)
The LSM2 antibody is a tool used to detect and study the LSM2 protein, a member of the Like Sm (LSM) family involved in RNA metabolism. LSM2 is a conserved component of the LSM protein complex, which plays critical roles in RNA processing, including pre-mRNA splicing, RNA degradation, and small nuclear RNA (snRNA) maturation. Specifically, LSM2 interacts with the U6 snRNA within the spliceosome, a dynamic machinery essential for removing introns during mRNA splicing. Dysregulation of LSM2 has been implicated in cellular stress responses, cancer progression, and neurological disorders, making it a target for disease-related research.
Antibodies against LSM2 are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions in various biological contexts. Studies have highlighted its role in maintaining RNA stability and regulating gene expression, particularly under stress conditions. For example, LSM2 knockdown has been linked to altered cell cycle control and increased sensitivity to DNA damage, suggesting its involvement in genomic integrity.
Researchers also utilize LSM2 antibodies to explore its potential as a biomarker or therapeutic target in cancers, where abnormal RNA processing is a hallmark. The antibody’s specificity and reliability are critical for dissecting LSM2’s molecular mechanisms and its contribution to pathologies, advancing both basic and translational research in RNA biology.
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