Rabbit Polyclonal NPTX1-Y344 Antibody

The NPTX1-Y344 antibody is a specialized tool designed to target a specific epitope within the neuronal pentraxin 1 (NPTX1) protein, a member of the pentraxin family involved in synaptic plasticity and neural circuit organization. NPTX1. also known as neuronal activity-regulated pentraxin, is primarily expressed in the central nervous system and plays a critical role in modulating excitatory synapse function by interacting with AMPA-type glutamate receptors. The "Y344" designation refers to a tyrosine residue at position 344 within the protein’s C-terminal domain, which may be associated with post-translational modifications or functional interactions. This antibody is commonly utilized in neuroscience research to investigate NPTX1’s involvement in synaptic remodeling, learning, and memory, as well as its potential dysregulation in neurological disorders such as Alzheimer’s disease, schizophrenia, or autism spectrum disorders. Its specificity for the Y344 epitope enables precise detection of NPTX1 isoforms or phosphorylation states in techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Recent studies also explore NPTX1’s role in cancer biology, where aberrant expression may influence tumor microenvironment signaling. Validation typically includes knockout controls and cross-reactivity assessments to ensure reliability across experimental models.