| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tripartite motif-containing protein 55, Muscle-specific RING finger protein 2, MuRF-2, MuRF2, RING finger protein 29, TRIM55, MURF2, RNF29 |
| Entrez GeneID | 84675 |
| WB Predicted band size | 60.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This TRIM55 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 216-250 amino acids from the Central region of human TRIM55. |
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以下是关于TRIM55抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *TRIM55 regulates sarcomere assembly and cardiac hypertrophy through ubiquitination of actin*
**作者**: Chen SN, et al.
**摘要**: 该研究利用TRIM55特异性抗体，发现TRIM55通过泛素化修饰肌动蛋白调控心肌细胞肌节组装，其表达下调与病理性心脏肥厚相关。实验表明TRIM55缺失导致小鼠心肌结构紊乱。
2. **文献名称**: *Muscle-specific E3 ubiquitin ligase TRIM55 suppresses skeletal muscle atrophy*
**作者**: Harada K, et al.
**摘要**: 研究通过TRIM55抗体检测其在骨骼肌中的表达，揭示TRIM55通过抑制泛素-蛋白酶体通路减轻肌肉萎缩。去神经支配模型中TRIM55表达降低，过表达可延缓萎缩进程。
3. **文献名称**: *TRIM55 interacts with dysferlin to regulate myoblast differentiation*
**作者**: Li H, et al.
**摘要**: 利用免疫共沉淀(TRIM55抗体)证实TRIM55与dysferlin蛋白互作，调控成肌细胞分化。研究发现TRIM55缺失导致肌管形成障碍，提示其在肌肉再生中的作用。
注：上述文献为示例，实际引用时需根据具体研究补充真实文献信息。若需最新文献，建议在PubMed等数据库检索关键词"TRIM55 antibody"或结合研究场景筛选。
TRIM55 (Tripartite Motif-Containing 55), also known as MURF2 (Muscle RING Finger 2), is a member of the TRIM protein family characterized by conserved RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, playing roles in ubiquitination-mediated protein degradation, cellular signaling, and muscle-specific processes. TRIM55 is predominantly expressed in skeletal and cardiac muscles, where it regulates myofiber structure, sarcomere organization, and muscle differentiation. Studies suggest its involvement in modulating stress responses, apoptosis, and hypertrophic pathways in cardiomyocytes, as well as interactions with cytoskeletal proteins like titin.
TRIM55 antibodies are essential tools for detecting and analyzing TRIM55 expression and function in research. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study TRIM55's localization, expression levels, and interactions in muscle tissues or cell models. These antibodies aid in exploring TRIM55's role in muscle atrophy, cardiac hypertrophy, and muscular dystrophies. Some studies also investigate its potential tumor-suppressive or oncogenic roles in certain cancers. Commercial TRIM55 antibodies are typically developed in hosts like rabbits or mice, with validation via knockout controls or siRNA-based silencing to ensure specificity. Research on TRIM55 continues to uncover its regulatory mechanisms in health and disease.
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