Rabbit Polyclonal PDE1A(N-Term) Antibody

The PDE1A (N-Term) antibody is a specialized immunological tool designed to target the N-terminal region of the phosphodiesterase 1A (PDE1A) enzyme, a member of the calcium/calmodulin-dependent PDE family. PDE1A plays a critical role in hydrolyzing cyclic nucleotides (cAMP and cGMP), key secondary messengers regulating diverse cellular processes such as smooth muscle contraction, neuronal signaling, and cardiac function. The N-terminal domain of PDE1A contains regulatory elements, including calmodulin-binding motifs, which modulate enzyme activity in response to intracellular calcium levels. Researchers utilize the PDE1A (N-Term) antibody primarily in applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study the expression, localization, and functional dynamics of PDE1A in tissues or cell lines. Its specificity for the N-terminal region ensures minimal cross-reactivity with other PDE isoforms, making it valuable for distinguishing PDE1A from closely related family members (e.g., PDE1B, PDE1C). This antibody has been instrumental in exploring PDE1A's involvement in pathophysiological conditions, including cardiovascular diseases, neurodegenerative disorders, and cancer, where dysregulated cyclic nucleotide signaling is implicated. Validated for use in human, mouse, and rat samples, it typically originates from rabbit or mouse hosts, with quality assessments confirming reactivity and low background noise. Its development underscores the importance of PDE1A as a therapeutic target and biomarker in translational research.