Mouse Monoclonal RAB3A Antibody

Rab3A is a small GTP-binding protein belonging to the Rab family, which plays a critical role in regulating synaptic vesicle trafficking and neurotransmitter release in neuronal and neuroendocrine cells. It cycles between GTP-bound (active) and GDP-bound (inactive) states, interacting with effector proteins like Rabphilin-3A and RIM to mediate vesicle docking, priming, and fusion at presynaptic membranes. Rab3A antibodies are widely used as research tools to study its expression, localization, and function in synaptic transmission, endocrine secretion, and related pathologies. These antibodies are essential for techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect Rab3A in brain tissues, cultured neurons, or secretory cells. Dysregulation of Rab3A has been implicated in neurological disorders (e.g., Alzheimer's disease, epilepsy) and endocrine tumors, making its detection valuable for both basic and clinical research. Commercial Rab3A antibodies are typically raised against specific epitopes, often validated using knockout controls to ensure specificity. They may exhibit cross-reactivity across species (human, mouse, rat) depending on the immunogen design. Recent studies also explore Rab3A's role in non-neuronal contexts, such as cancer cell exocytosis and immune signaling, expanding the utility of these antibodies in diverse research fields.