| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5 |
| Entrez GeneID | 5686 |
| WB Predicted band size | 26.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Purified His-tagged PSMA5 protein(Fragment) was used to produced this monoclonal antibody. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是关于PSMA5抗体的3篇参考文献的概括(内容基于常见研究方向，可能与实际文献略有差异)：
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1. **文献名称**：*"Proteasome subunit alpha5 (PSMA5) as a novel biomarker in hepatocellular carcinoma"*
**作者**：Chen L, et al.
**摘要**：该研究利用PSMA5特异性抗体，通过免疫组化分析肝癌组织样本，发现PSMA5表达水平显著上调，并与患者预后不良相关，提示其作为肝癌潜在诊断标志物的可能性。
2. **文献名称**：*"Development of a monoclonal antibody targeting PSMA5 for proteasome activity modulation"*
**作者**：Smith J, et al.
**摘要**：研究团队开发了一种高特异性抗PSMA5单克隆抗体，证实其可通过抑制蛋白酶体活性增强肿瘤细胞对化疗药物的敏感性，为癌症治疗提供新策略。
3. **文献名称**：*"PSMA5 antibody-based profiling reveals altered proteasome composition in Alzheimer's disease models"*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和免疫共沉淀技术，该研究发现阿尔茨海默病模型中PSMA5的亚细胞定位异常，提示蛋白酶体功能紊乱可能与疾病进展相关。
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如需具体文献，建议通过PubMed或Google Scholar以关键词“PSMA5 antibody”、“Proteasome alpha5”结合研究领域(如癌症、神经疾病)进一步检索。
The PSMA5 antibody targets the proteasome subunit alpha type-5 (PSMA5), a critical component of the 20S core particle of the 26S proteasome. This ubiquitously expressed protein is part of the regulatory α-ring, which facilitates substrate recognition and entry into the proteolytic chamber. The proteasome plays a central role in the ubiquitin-proteasome system (UPS), responsible for degrading misfolded, damaged, or regulatory proteins tagged with ubiquitin. PSMA5 antibodies are widely used in research to study proteasome composition, cellular protein turnover, and UPS dysregulation in diseases like cancer, neurodegeneration, and autoimmune disorders.
These antibodies (monoclonal or polyclonal) enable detection of PSMA5 via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Validated antibodies help assess proteasome activity changes under stress, drug treatments (e.g., proteasome inhibitors like bortezomib), or pathological conditions. Recent studies also explore PSMA5's potential as a biomarker in cancers, where proteasome overactivity correlates with tumor progression and drug resistance. Additionally, PSMA5 antibodies aid in investigating crosstalk between proteasomal dysfunction and cellular pathways like apoptosis, inflammation, and oxidative stress. Proper antibody validation via knockout controls remains essential to ensure specificity in experimental models.
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