Mouse Monoclonal ALDOC Antibody

The ALDOC antibody targets aldolase C, a glycolytic enzyme encoded by the ALDOC gene, primarily expressed in the brain, particularly in cerebellar Purkinje cells and retinal neurons. As a member of the aldolase family (ALDOA, ALDOB, ALDOC), it catalyzes fructose-1.6-bisphosphate cleavage in glycolysis and gluconeogenesis. Beyond metabolism, ALDOC is implicated in non-glycolytic roles, including cytoskeletal interactions and cellular stress responses. ALDOC antibodies are vital tools in neuroscience research, aiding studies on brain development, neurodegeneration (e.g., ataxia, spinocerebellar disorders), and retinal diseases. In cancer research, ALDOC expression loss is linked to gliomas and other tumors, suggesting tumor-suppressive potential. These antibodies are also used diagnostically to distinguish ALDOC from other aldolase isoforms in tissue-specific studies. Commercial ALDOC antibodies (polyclonal/monoclonal) enable techniques like Western blot, immunohistochemistry, and immunofluorescence. However, variability in antibody specificity requires careful validation. Recent studies explore ALDOC’s role in hypoxia adaptation and neuroprotection, highlighting its broader biomedical relevance.