| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Vasopressin V1a receptor, V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor, AVPR1A, AVPR1 |
| Entrez GeneID | 552 |
| WB Predicted band size | 46.8kDa |
| Host/Isotype | Mouse IgM |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This AVPR1A Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 353-383 region of human AVPR1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AVPR1A抗体的3篇模拟参考文献示例(注：以下内容为示例，实际文献需根据具体研究查询补充)：
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1. **文献名称**：*"Characterization of AVPR1A Antibody Specificity in Rodent Brain Tissue"*
**作者**：Smith J, et al.
**摘要**：本研究验证了一种新型AVPR1A抗体的特异性，通过免疫组化和Western blot分析，证实其在啮齿类动物前额叶皮层、杏仁核等脑区的高表达，且与AVPR1B无交叉反应，适用于神经环路研究。
2. **文献名称**：*"AVPR1A Gene Polymorphisms and Social Behavior: Antibody-Based Receptor Quantification"*
**作者**：Lee S, et al.
**摘要**：利用AVPR1A抗体定量分析人类大脑样本中受体表达水平，发现特定基因变异(如RS3)与自闭症谱系障碍患者的社交功能缺陷显著相关，提示受体表达异常可能影响行为表型。
3. **文献名称**：*"Localization of AVPR1A in Mouse Hypothalamus Using Immunofluorescence"*
**作者**：Garcia R, et al.
**摘要**：通过高分辨率免疫荧光技术，系统描绘了AVPR1A受体在小鼠下丘脑室旁核和视上核的分布，揭示了其在调节应激反应和体液平衡中的潜在作用，并提供了抗体优化方案。
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如需实际文献，建议在PubMed或Web of Science中搜索关键词“AVPR1A antibody”+“validation”或“application”，并筛选近年的研究。
The arginine vasopressin receptor 1A (AVPR1A) is a G protein-coupled receptor that binds vasopressin, a neuropeptide involved in regulating physiological processes such as water retention, blood pressure, and social behaviors. Primarily expressed in the kidney, liver, vascular smooth muscle, and brain regions (e.g., hypothalamus and amygdala), AVPR1A mediates vasopressin's effects via intracellular signaling pathways, including cAMP and calcium mobilization. Dysregulation of AVPR1A has been linked to neuropsychiatric conditions (e.g., autism, anxiety) and cardiovascular disorders.
AVPR1A antibodies are essential tools for studying the receptor's expression, localization, and function. These antibodies, typically raised against specific epitopes (e.g., extracellular loops or intracellular domains), are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use them to explore AVPR1A's role in social cognition, stress responses, and fluid homeostasis, as well as its interaction with genetic or pharmacological modulators. Challenges include ensuring specificity due to homology with related receptors (e.g., AVPR1B) and detecting low-abundance receptor levels in tissue samples. Proper validation via knockout controls or blocking peptides is critical for reliable data.
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